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Rebamipide ameliorates hepatic dysfunction induced by ischemia/reperfusion in rats
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2021-12-27T17:16:49Z | - |
dc.date.available | 2021-12-27T17:16:49Z | - |
dc.date.issued | 1995-12 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186521 | - |
dc.description.abstract | The relationship between lipid peroxidation and alterations in hepatic secretory function and microsomal function during hepatic ischemia/reperfusion was studied. Rats pretreated with free radical scavengers were subjected to 60 min of hepatic ischemia and to 1 and 5 h of reperfusion thereafter. Serum aminotransferase level and microsomal lipid peroxidation were markedly increased by ischemia/reperfusion. These increases were significantly attenuated by rebamipide, α-tocopherol or allopurinol. Bile flow and cholate output were markedly decreased by ischemia/reperfusion and free radical scavengers, especially rebamipide, restored their secretion. NADPH-cytochrome P450 reductase activity and cytochrome P450 content were decreased by ischemia/reperfusion. Rebamipide prevented the decrease of the NADPH-cytochrome P450 reductase activity but had little effect on the cytochrome P450 content. AminopyrineN-demethylase activity was decreased and anilinep-hydroxylase was increased by ischemia/reperfusion, which were prevented by α-tocopherol and allopurinol, but not by rebamipide. Our findings suggest that ischemia/reperfusion diminishes hepatic secretory function and microsomal function by increasing lipid peroxidation, and rebamipide significantly ameliorates these changes through its free radical scavenging activity. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF PHARMACOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alanine / analogs & derivatives* | - |
dc.subject.MESH | Alanine / therapeutic use | - |
dc.subject.MESH | Alanine Transaminase / blood | - |
dc.subject.MESH | Allopurinol / pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bile / drug effects | - |
dc.subject.MESH | Bile / metabolism | - |
dc.subject.MESH | Enzyme Inhibitors / pharmacology | - |
dc.subject.MESH | Free Radical Scavengers / pharmacology | - |
dc.subject.MESH | Lipid Peroxidation / drug effects | - |
dc.subject.MESH | Liver Diseases / drug therapy* | - |
dc.subject.MESH | Liver Diseases / pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Microsomes, Liver / drug effects | - |
dc.subject.MESH | Microsomes, Liver / enzymology | - |
dc.subject.MESH | Mixed Function Oxygenases / metabolism | - |
dc.subject.MESH | NADPH-Ferrihemoprotein Reductase / metabolism | - |
dc.subject.MESH | Organ Size / drug effects | - |
dc.subject.MESH | Quinolones / therapeutic use* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reperfusion Injury / drug therapy* | - |
dc.subject.MESH | Reperfusion Injury / pathology | - |
dc.subject.MESH | Vitamin E / pharmacology | - |
dc.subject.MESH | Xanthine Oxidase / antagonists & inhibitors | - |
dc.title | Rebamipide ameliorates hepatic dysfunction induced by ischemia/reperfusion in rats | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Sun-Mee Lee | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.identifier.doi | 10.1016/0014-2999(95)00507-2 | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J00842 | - |
dc.identifier.eissn | 1879-0712 | - |
dc.identifier.pmid | 8788414 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/0014299995005072 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 294 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 41 | - |
dc.citation.endPage | 46 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF PHARMACOLOGY, Vol.294(1) : 41-46, 1995-12 | - |
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