Levofloxacin과 흔히 사용되는 항균제의 호기성 세균에 대한 시험관내 항균력

Abstract

Background : Levofloxacin(LVFX), an optical isomer of ofloxacin (OFLX), was reported to be approximately two-fold more active against aerobic bacteria than OFLX, but the antimicrobial activity against Korean isolates of bacteria has not been compared yet. Theaim of this study was to compare the activity of LVFX to those of other commonly used antimicrobial agents, including OFLX and ciprofloxacin (CPFX). Methods : Aerobic bacteria, which were isolated from patients at Severance Hospital, during the years 1980 to 1994, were tested by the NCCLS agar dilution method. Results : Minimum inhibitory concentrations of CPFX, LVFX and OFLX for 90% of thestrains were: ≤ 1μg/mL for Klebsiella oxytoca (KOX), Enterobacter aerogenes(EAE), Proteus sp., Morganella morganii, Salmonella serovars (SAL), Shigella flexneri (SFL) and Yersinia enterocolitica (YEN); 4~8μg/mL for Citrobacter freundii, E. cloacae (ECL), Xanthomonas maltophilia (XMA); ≥ 8μg/mL for other gram-negative bacilli; ≤ 0.25~4μg/mL for Moraxella (Branhamella) catarrhalis and gram-positive cocci. All isolates of the KOX, EAE, SAL, SFL and YEN were susceptible to the fluoroquinolones. Pseudomonas aeruginosa were more often susceptible to CPFX and LVFX, and ECL and XMA more often to LVFX than to the other fluoroquinolones. Conclusion : The higher in vitro activity of fluoroquinolones against various aerobic bacteria, compared to the other commonly used antimicrobial agents and the slightly higher activity of LVFX against some species of bacteria strongly suggest that LVFX may be more useful in the treatment of various aerobic infections.