Cited 0 times in
Discrepancy in T cell clonal expansions in synovial fluid and peripheral blood from rheumatoid arthritis patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김세종 | - |
dc.contributor.author | 이수곤 | - |
dc.date.accessioned | 2021-12-27T17:08:02Z | - |
dc.date.available | 2021-12-27T17:08:02Z | - |
dc.date.issued | 1995-03 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186408 | - |
dc.description.abstract | Rheumatoid arthritis (RA) is an autoimmune disease involving the synovial membrane of peripheral joints. T cells specific for self antigens may play a critical role. Identification of T cell receptors (TCR) of such specific T cell clones is very important for treatment, prevention and identification of relevant autoantigens. To identify specific T cells, TCR V β family repertoire and the clonal expansion of T cells were analyzed in this study. The percentage of V β 5+ or V β 8+ cells in the synovial fluid mononuclear cells (SFMCs) was similar to that in the peripheral blood mononuclear cells (PBMCs). However, the percentage of DR+ T cells in the SFMCs was higher (p< 0.01). Analyzing the clonality of T cells in 8 V β families (V β 1, V β 5, V β 8, V β 14, V β 16, V β 17, V β 18, V β 20), clonal expansions in CD8+ T cells from the SFMCs were found more frequently than in the PBMCs. The patterns of clonal expansions were discrepant between the SFMCs and the PBMCs even in the same patient, which suggests several inflamed tissue specific T cell clonal expansions in the SFMCs. These T cell clones might be activated by autoantigens which are not identified yet and responsible for the RA pathogenesis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Arthritis, Rheumatoid / metabolism* | - |
dc.subject.MESH | Arthritis, Rheumatoid / pathology | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Blood Cells / metabolism* | - |
dc.subject.MESH | Clone Cells | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Molecular Probes | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Polymerase Chain Reaction | - |
dc.subject.MESH | Receptors, Antigen, T-Cell / genetics | - |
dc.subject.MESH | Receptors, Antigen, T-Cell / metabolism* | - |
dc.subject.MESH | Synovial Fluid / cytology | - |
dc.subject.MESH | Synovial Fluid / metabolism* | - |
dc.subject.MESH | T-Lymphocytes / metabolism* | - |
dc.title | Discrepancy in T cell clonal expansions in synovial fluid and peripheral blood from rheumatoid arthritis patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Choi In Hong | - |
dc.contributor.googleauthor | Chwae Youngjoon | - |
dc.contributor.googleauthor | Lee Soo Kon | - |
dc.contributor.googleauthor | Chu Minkyung | - |
dc.contributor.googleauthor | Kim Joo Deuk | - |
dc.contributor.googleauthor | Kim Se Jong | - |
dc.identifier.doi | 10.3349/ymj.1995.36.1.68 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A02889 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 7740838 | - |
dc.subject.keyword | Rheumatoid arthritis | - |
dc.subject.keyword | synovial fluid T cells | - |
dc.subject.keyword | T cell receptor | - |
dc.subject.keyword | CDR3 | - |
dc.subject.keyword | clonal expansions | - |
dc.subject.keyword | DR+ T cells | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | 김세종 | - |
dc.contributor.affiliatedAuthor | 이수곤 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 68 | - |
dc.citation.endPage | 76 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.36(1) : 68-76, 1995-03 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.