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전이 전립선암 환자에서 Maximum Androgen Blocking후 혈중 전립선특이항원의 변화와 Gleason score와의 관계

Other Titles
 Tht Gleas on Score and the Change of Serum PSA after Maximum Androgen Blocking in Patients with Metastatic Prostate Cancer 
 이동현  ;  홍성준  ;  정병하 
 Korean Journal of Urology (대한비뇨기과학회지), Vol.36(8) : 815-818, 1995-08 
Journal Title
Issue Date
The prostate specific antigen(PSA) has the most available clinical value in monitoring the disease status and treatment response, especially in patients with advanced metastatic adenocarcinoma of prostate. Between March 1992 and May 1994, 22 patients with newly diagnosed metastatic prostate cancer received gonadotropin-releasing hormone analogue monthly and antiandrogen daily. The 15 patients whose serum PSA levels were normalized within the first 3 months had serum PSA level of 71.3 ± 22.7 ng/ml at the time of diagnosis and their Gleason score was 6.2 ± 1.3. The other 7 whose serum PSA levels were not normalized even after hormonal treatment, had 75.6 ± 39.1 ng/ml of serum PSA level at the time of diagnosis and their Gleason score was 8.71 ± 0.98. There was not signifcantly different in PSA levels but in Gleason scores between the two groups at diagnosis. So the serum PSA level of patients with low Gleason score have a tendency to be normalized within 3 months of hormonal treatment. And we suggest that the normalization of serum PSA level after 3 months treatment might be the earliest and most highly correlated predictor of response or prognosis.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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