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C형 간염 항체 양성인 말기 신부전증 환자에서 신이식후의 임상경과에 관한 연구

Other Titles
 The Clinical Outcome of Anti - HCV ( + ) Renal Allograft Recipients 
Authors
 이승우  ;  강신욱  ;  최규헌  ;  한광협  ;  이호영  ;  한대석  ;  김명수  ;  김유선  ;  박기일 
Citation
 Journal of the Korean Society for Transplantation, Vol.9(1) : 115-118, 1995-12 
Journal Title
Journal of the Korean Society for Transplantation(대한이식학회지)
ISSN
 1298-1711 
Issue Date
1995-12
Abstract
This study showed that the anti-HCV(+) recipients had higher incidence of
post-transplant hepatic dysfunction than the anti-HCV(-) recipients, which was
consistent with previous reports. There have been conflicting reports on the rate of
acute rejection, extra-hepatic infection, and mortality from hepatic failure in anti-HCV(+)
recipients. In our study, there were no significant differences in these parameters
between the anti-HCV(+) and (-) recipients. As the possible explanation for conflicting
reports, the variability in HCV strain virulence, viral burden and different immunosuppressive regimen can be suggested. The greater number of acute rejection was observed in the recipients with normal histology, but studies in a larger number of patients should be needed for confirmation. The graft and patient survival in
anti-HCV(+) recipients were not significantly different from those in anti-HCV(-) recipients in short-term follow-up. There was also no difference in graft or patient
survival between CPH and carrier status recipients. From these results, it seems that anti-HCV(+) is not a poor prognostic indicator. Two HCV-RNA(+) recipients maintained relatively stable liver function, suggesting the low sensitivity of liver enzymes to detect active viral replications. In conclusion, the graft and patient survival appear not to be influenced by anti-HCV status in short-term follow-up, but long-term follow-up with close monitoring should be required in view of the increased risk for posttransplant hepatic dysfunction.
Files in This Item:
T199501134.pdf Download
DOI
10.4285/.1995.9.1.115
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/186299
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