기관지 천식에서 급성 발작기와 호전기의 Interleukin - 6 치의 변동에 관한 연구

Abstract

Asthma is a chronic obstructive airway disease. It is characterized by episodic exacerbations of reversible airflow obstruction along with bronchial hyperreactivity and airway inflammation. The airway inflammation is now a major focus of investigation because of its critical role in pathogenesis of asthma. Interleukin-6(IL-6) is a multifunctional cytokine, which has a major role in induction of inflammatory and immune reaction. Althouth the exact functions of IL-6 in asthma pathogenesis are unknown, we studied serun IL-6 level in acute asthma attack and exercise-induced asthma during acute and convalescent phase and tried to investigate their relationship with the clinical menifestation of in asthma. The results were as follows ' 1) In acute asthma attack, the mean serum IL-6 level markedly increased to 31.6 pg/ml at acute stage and decreased to 16.0 pg/ml at convalescent stage(P<0.01). 2) In exercise-induced asthma, the mean serum IL-6 level before exercise was 7.9 pg/ml and after-exercise level was 7.7 pg/ml. There was no significant difference. 3) In pneumonia, serum IL-6 level increased to 25.7 pg/ml at acute stage and decreased to 13.3 pg/ml at convalescent stage(P<0.05). 4) There was no significant correlation between serum IL-6 level at acute stage and the severity of clinical manifestation.