위암 환자에서의 Helicobacter pylori IgG 항체 양성률과 혈청 Pepsinogen Ⅰ 및 Ⅱ 농도

Abstract

Objectives: Helicobacter pylori(H. pylori) infection, thought to causally related to peptic ulcer and chronic antral gastritis, may also be associated with gastric cancer. A considerable number of normal subjects in Korea were infected with H. pylori infection. In gastric carcinogensis serum pepsinogen I and II levels may be indicator of precancerous lesions such as atrophic gastritis and intestinal metaplasia, which were known to associated with gastric cancer and may be induced by H, pylori infection. Methods: The levels of serum H. pylori IgG antibody were measured using enzyme-linked immunosorbent assay and the levels of serum pepsinogen I and II using immunoradiometric assay in 174 gastric cancer patients and 165 controls. Results: There was no statistically significant difference between the positive incidence of H. pylori infection in gastric cancer patient (60.3%) and in control group (70.9%). Antibodies to H. pylori were detected in 64.8% of non-cardiac gastric cancer patients but in only 12.5% of cardiac gastric cancer patients (p<0.05). The positive incidences of H, pylori infection in intestinal and diffuse histologic type of gastric cancer were similar. Serum pepsinogen I and II levels were higher in H. pylori-infected controls than in uninfected controls (p<0.05). Serum pepsinogen I levels was lower in gastric cancer patients than control group (p<0.05). However, there was no difference in serum pepsinogen I and II levels between H. pylori-infected and uninfected gastric cancer patients. Conclusion: The positive incidence of H. pylori infection in gastric cancer was similar to that in controls and there was no evidence of the direct relationship between H, pylori infection and gastric carcinogensis.