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Induction of ICAM-1 and HLA-DR expression by IFN-γ in malignant melanoma cell lines
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 박전한 | - |
dc.date.accessioned | 2021-12-27T16:50:57Z | - |
dc.date.available | 2021-12-27T16:50:57Z | - |
dc.date.issued | 1995-03 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/186192 | - |
dc.description.abstract | Two human malignant melanoma cell lines, Malme-3M and SK-Mel-28, were analyzed for their ability to induce the expression of intercellular adhesion molecule 1 (ICAM-1) and human leukocyte antigen (HLA)-DR molecules on their cell surfaces as well as at the transcriptional level before and after treatment with interferon (IFN)-γ. Both cell lines demonstrated a high percentage(> 99% ) of ICAM-1 expression regardless of IFN-γ treatment. Before IFN-γ treatment, Malme-3M cells barely expressed HLA-DR molecules (< 2% ) and SK-Mel-28 cells demonstrated a relatively high percentage(> 50% ) of HLA-DR expression. Both cell lines displayed elevated levels of HLA-DR expression in a time dependent manner after IFN-γ treatment. However, these two cell lines have been shown to respond differentially to IFN-γ. The molecular mechanism underlying such a differential behavior was investigated, and HLA-DR gene regulation was studied at the transcriptional level. Treatment with IFN-γ led to the steady-state mRNA augmentation of the HLR-DR gene. The HLA-DRA mRNA augmentation was similar in both cell lines, whereas in Malme-3M, IFN-γ did not augment the rate of transcription of the HLA-DRB gene as much as in SK-Mel-28. Data from this study established the fact that the melanoma cell lines displayed a differential susceptibility to IFN-γ on the modulation of HLA-DR molecules, and this modulation was transcriptionally regulated. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Yonsei University | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Genes, MHC Class II | - |
dc.subject.MESH | HLA-DR Antigens / metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Intercellular Adhesion Molecule-1 / metabolism* | - |
dc.subject.MESH | Interferon-gamma / pharmacology* | - |
dc.subject.MESH | Melanoma / metabolism* | - |
dc.subject.MESH | Melanoma / pathology | - |
dc.subject.MESH | Transcription, Genetic | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.title | Induction of ICAM-1 and HLA-DR expression by IFN-γ in malignant melanoma cell lines | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Joo Deuk Kim | - |
dc.contributor.googleauthor | Jung Lim Lee | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Jae Myun Lee | - |
dc.contributor.googleauthor | Yeon Hyang Kim | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.identifier.doi | 10.3349/ymj.1995.36.1.15 | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A01641 | - |
dc.relation.journalcode | J02813 | - |
dc.identifier.eissn | 1976-2437 | - |
dc.identifier.pmid | 7740833 | - |
dc.subject.keyword | Malignant melanoma cell lines | - |
dc.subject.keyword | ICAM-1 | - |
dc.subject.keyword | HLA-DR expression | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | transcriptional regulation | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | 김세종 | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.citation.volume | 36 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 15 | - |
dc.citation.endPage | 25 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, Vol.36(1) : 15-25, 1995-03 | - |
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