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Assessment of the Synovial Inflammation in Rheumatoid Arthritis with 99mTc-labelled Polyclonal Human IgG(HIG): Prospective Comparison with Gadolinium Enhanced MRI

Other Titles
 99mTc-labelled HIG 스캔을 이용한 류마티스 관절염 환자에서 활막염증의 평가 : 조영증강 자기공명영상과의 전향적인 비교 
 Young Hoon Ryu  ;  Jong Doo Lee  ;  Jin Suck Suh  ;  Chang Yun Park  ;  Pyoung Jeon  ;  Jae Beom Na  ;  Soo Kon Lee 
 Korean Journal of Nuclear Medicine (대한핵의학회지), Vol.28(1) : 84-91, 1995-01 
Journal Title
Korean Journal of Nuclear Medicine(대한핵의학회지)
Issue Date
Many clinical and laboratory tests have been employed to evaluate disease activity in rheumatioid arthritis. 99mTc-labelled polyclonal IgG(HIG) has been demonstrated to accumulate in focal sites of infection or inflammation in both animals and human subjects. The purpose of this study was to distinguish arthritis with active inflammation from those without active inflammation and to correlate relative intensities of 99mTc-labelled HIG uptake of the rheumatoid arthritis with clinical and MR indices of the joint inflammation. This study included twelve patients with active rheumatoid arthritis, two with ankylosing spondylitis and one with degenerative osteoarthritis without active inflammation. A Whole-body and spot images were obtained 4 hours after intravenous injection of 20mCi of 99mTc-labelled HIG. Scintigrams were assessed visually by 3 experienced radiologists, and graded as normal or mildly and markedly increased uptake within the joints, and the degree of uptake was compared with clinical and radiologic severity of synovial inflammation. MRI studies were done on the involved joints consisted of wrist(n = 11), knee(n = 2) and hip joint(n= 2). Active synovitis was defined when marked elevation of ESR and gadolinium enhancement of synovium on MRI were demonstrated. Markedly increased radiotracer uptake was seen in 10 of 11 rheumatoid arthritic patients with active synovitis whereas normal or mildly increased uptakes were noted in others, including rheumatoid arthritic patient(n=1) and non-rheumatoid patients(n = 3) without active synovitis. This study showed that the localization of involved joints in rheumatoid arthritis could be detected with 99mTc-labelled HIG and that the degree of uptake correlated well with the degree and activity of inflammation. In conclusion, 99mTc-labelled HIG scan is a useful method in the evaluation of active inflammation in rheumatoid arthritis.
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1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jong Doo(이종두)
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