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Changes in Strain Pattern and Exercise Capacity after Transcatheter Closure of Atrial Septal Defects

Authors
 Jung Yoon Kim  ;  Bong-Sic Yun  ;  Sunho Lee  ;  Se Yong Jung  ;  Jae Young Choind Nam Kyun Kim  ;  MD1 
Citation
 Korean Circulation Journal, Vol.47(2) : 245-253, 2017-05 
Journal Title
 Korean Circulation Journal 
Issue Date
2017-05
Keywords
Cardiopulmonary exercise tests ; Atrial septal defect ; Strain ; Brain natriuretic peptide
Abstract
Background and Objectives: Assessment of left ventricle (LV) function by using strain and strain rate is popular in the clinical setting.
However, the use of these echocardiographic tools in assessing right ventricle (RV) failure, and the manner in which they both reflect the
functional capacity of the patient, remains poorly understood. This study aimed to investigate the change in exercise capacity and strain
between before and (1 month) after the transcatheter closure of atrial septal defects (ASDs).
Subjects and Methods: Thirty patients who underwent transcatheter closure of ASD between May 2014 and June 2015 at the Division of
Pediatric Cardiology, Severance Cardiovascular Hospital, were enrolled. We compared and analyzed the results of the following
examinations, before and (1 month) after the procedure: echocardiography, cardiopulmonary exercise test (CPET), and N-terminal probrain
natriuretic peptide level.
Results: There were no mortalities, and the male-to-female ratio was 1:2. The mean defect size was 22.3±4.9 mm; the mean ratio of
pulmonary to systemic flow, 2.1±0.5; and the mean device size, 22.3±4.9 mm. Changes in global RV longitudinal (GRVL) strain and LV
torsion were measured echocardiographically. Exercise capacity improved from 7.7±1.2 to 8.7±1.8 metabolic equivalents (p=0.001). These
findings correlated to the change in GRVL strain (p=0.03).
Conclusion: The average exercise capacity increased after device closure of ASD. The change in strain was evident on echocardiography,
especially for GRVL strain and LV torsion. Further studies comparing CPET and strain in various patients may show increased exercise
capacity in patients with improved RV function.
Files in This Item:
T999201706.pdf Download
DOI
10.4070/kcj.2016.0205
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Nam Kyun(김남균) ORCID logo https://orcid.org/0000-0001-6923-230X
Kim, Jung Yoon(김정윤)
Lee, Sun Ho(이선호)
Jung, Se Yong(정세용) ORCID logo https://orcid.org/0000-0003-1337-563X
Choi, Jae Young(최재영) ORCID logo https://orcid.org/0000-0002-1247-6669
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185991
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