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The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2
DC Field | Value | Language |
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dc.contributor.author | 곽만섭 | - |
dc.contributor.author | 박인호 | - |
dc.contributor.author | 신전수 | - |
dc.date.accessioned | 2021-11-19T01:36:04Z | - |
dc.date.available | 2021-11-19T01:36:04Z | - |
dc.date.issued | 2021-10 | - |
dc.identifier.issn | 1076-1551 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185936 | - |
dc.description.abstract | Background: C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor 2 (DDR2) is activated by collagen and functions in wound healing by controlling matrix metalloproteinase (MMP) expression. Since C1q exhibits a collagen-like structure, we hypothesized that C1q might engage DDR2 to regulate wound healing and extracellular matrix (ECM) remodeling. Methods: Cell-based assay, proximity ligation assay, ELISA, and surface plasmon analysis were utilized to investigate DDR2 and C1q binding. We also investigate the C1q-mediated in vitro wound healing ability using the human fibrosarcoma cell line, HT1080. Results: C1q induced the phosphorylation of DDR2, p38 kinase, and ERK1/2. C1q and DDR2 binding improved cell migration and induced MMP2 and MMP9 expression. DDR2-specific shRNA reduced C1q-mediated cell migration for wound healing. Conclusions: C1q is a new DDR2 ligand that promotes wound healing. These findings have therapeutic implications in wound healing-related diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Feinstein Institute for Medical Research | - |
dc.relation.isPartOf | MOLECULAR MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The collagen structure of C1q induces wound healing by engaging discoidin domain receptor 2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Ria Aryani Hayuningtyas | - |
dc.contributor.googleauthor | Myeonggil Han | - |
dc.contributor.googleauthor | Seoyeon Choi | - |
dc.contributor.googleauthor | Man Sup Kwak | - |
dc.contributor.googleauthor | In Ho Park | - |
dc.contributor.googleauthor | Ji-Hyun Lee | - |
dc.contributor.googleauthor | Ji Eun Choi | - |
dc.contributor.googleauthor | Dae Ki Kim | - |
dc.contributor.googleauthor | Myoungsun Son | - |
dc.contributor.googleauthor | Jeon-Soo Shin | - |
dc.identifier.doi | 10.1186/s10020-021-00388-y | - |
dc.contributor.localId | A00166 | - |
dc.contributor.localId | A01631 | - |
dc.contributor.localId | A02144 | - |
dc.relation.journalcode | J02260 | - |
dc.identifier.eissn | 1528-3658 | - |
dc.identifier.pmid | 34602056 | - |
dc.subject.keyword | C1q | - |
dc.subject.keyword | Collagen | - |
dc.subject.keyword | DDR2 | - |
dc.subject.keyword | Wound healing | - |
dc.contributor.alternativeName | Kwak, Man Sup | - |
dc.contributor.affiliatedAuthor | 곽만섭 | - |
dc.contributor.affiliatedAuthor | 박인호 | - |
dc.contributor.affiliatedAuthor | 신전수 | - |
dc.citation.volume | 27 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 125 | - |
dc.identifier.bibliographicCitation | MOLECULAR MEDICINE, Vol.27(1) : 125, 2021-10 | - |
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