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The ratio of triglycerides to high-density lipoprotein cholesterol is associated with the risk of chronic kidney disease in Korean men
DC Field | Value | Language |
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dc.contributor.author | 김정연 | - |
dc.date.accessioned | 2021-10-21T00:17:16Z | - |
dc.date.available | 2021-10-21T00:17:16Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.issn | 0024-4201 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185458 | - |
dc.description.abstract | Dyslipidemia is nephrotoxic and can result in the development of chronic kidney disease (CKD). The ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) (TG/HDL-C ratio) is well-correlated with insulin resistance and cardiovascular events. The aim of this study is to examine the association between the TG/HDL-C ratio and CKD in Korean adults. This study was retrospectively designed based on the National Health Insurance Service-National Health Screening cohort. Seventy three thousand and fifty-two participants aged between 40 and 79 years old at baseline (2009-2010) were included in the final analyses. The study population was classified into three tertile groups (T1 , T2 , and T3 ) according to the TG/HDL-C ratio by sex. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CKD were calculated using Cox proportional hazard regression models. The median follow-up duration was 5.9 years. Higher tertile groups of the TG/HDL-C ratio had lower estimated glomerular filtration rates in both sexes. The cumulative incidence of CKD of T1 , T2 , and T3 was 11.89%, 12.90%, and 12.91%, respectively, in men and 10.17%, 10.61%, and 14.87%, respectively, in women (all p values < 0.001). Compared with T1 of the TG/HDL-C ratio, the HRs (95% CIs) of T2 and T3 for CKD were 1.212 (1.118-1.315) and 1.183 (1.087-1.287), respectively, in men and 0.895 (0.806-0.994) and 1.038 (0.937-1.150), respectively, in women after being fully adjusted. Higher TG/HDL-C ratios were positively associated with CKD development in men, while middle levels of TG/HDL ratios reduced the CKD incidence in women. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Oil Chemists' Society | - |
dc.relation.isPartOf | LIPIDS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | The ratio of triglycerides to high-density lipoprotein cholesterol is associated with the risk of chronic kidney disease in Korean men | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing (간호학과) | - |
dc.contributor.googleauthor | Joungyoun Kim | - |
dc.contributor.googleauthor | Yoon-Jong Bae | - |
dc.contributor.googleauthor | Sang-Jun Shin | - |
dc.contributor.googleauthor | Hyo-Sun You | - |
dc.contributor.googleauthor | Jae-Woo Lee | - |
dc.contributor.googleauthor | Hee-Taik Kang | - |
dc.identifier.doi | 10.1002/lipd.12314 | - |
dc.contributor.localId | A06089 | - |
dc.relation.journalcode | J03196 | - |
dc.identifier.eissn | 1558-9307 | - |
dc.identifier.pmid | 34089267 | - |
dc.identifier.url | https://aocs.onlinelibrary.wiley.com/doi/10.1002/lipd.12314 | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | glomerular filtration rate | - |
dc.subject.keyword | high-density lipoprotein cholesterol | - |
dc.subject.keyword | proteinuria | - |
dc.subject.keyword | triglyceride | - |
dc.contributor.alternativeName | Joungyoun Kim | - |
dc.contributor.affiliatedAuthor | 김정연 | - |
dc.citation.volume | 56 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 475 | - |
dc.citation.endPage | 483 | - |
dc.identifier.bibliographicCitation | LIPIDS, Vol.56(5) : 475-483, 2021-09 | - |
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