49 72

Cited 0 times in

Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies?

Authors
 JooYong Park  ;  Ji-Yeob Choi  ;  Jaesung Choi  ;  Seokang Chung  ;  Nan Song  ;  Sue K Park  ;  Wonshik Han  ;  Dong-Young Noh  ;  Sei-Hyun Ahn  ;  Jong Won Lee  ;  Mi Kyung Kim  ;  Sun Ha Jee  ;  Wanqing Wen  ;  Manjeet K Bolla  ;  Qin Wang  ;  Joe Dennis  ;  Kyriaki Michailidou  ;  Mitul Shah  ;  Don M Conroy  ;  Patricia A Harrington  ;  Rebecca Mayes  ;  Kamila Czene  ;  Per Hall  ;  Lauren R Teras  ;  Alpa V Patel  ;  Fergus J Couch  ;  Janet E Olson  ;  Elinor J Sawyer  ;  Rebecca Roylance  ;  Stig E Bojesen  ;  Henrik Flyger  ;  Diether Lambrechts  ;  Adinda Baten  ;  Keitaro Matsuo  ;  Hidemi Ito  ;  Pascal Guénel  ;  Thérèse Truong  ;  Renske Keeman  ;  Marjanka K Schmidt  ;  Anna H Wu  ;  Chiu-Chen Tseng  ;  Angela Cox  ;  Simon S Cross  ;  kConFab Investigators  ;  Irene L Andrulis  ;  John L Hopper  ;  Melissa C Southey  ;  Pei-Ei Wu  ;  Chen-Yang Shen  ;  Peter A Fasching  ;  Arif B Ekici  ;  Kenneth Muir  ;  Artitaya Lophatananon  ;  Hermann Brenner  ;  Volker Arndt  ;  Michael E Jones  ;  Anthony J Swerdlow  ;  Reiner Hoppe  ;  Yon-Dschun Ko  ;  Mikael Hartman  ;  Jingmei Li  ;  Arto Mannermaa  ;  Jaana M Hartikainen  ;  Javier Benitez  ;  Anna González-Neira  ;  Christopher A Haiman  ;  Thilo Dörk  ;  Natalia V Bogdanova  ;  Soo Hwang Teo  ;  Nur Aishah Mohd Taib  ;  Olivia Fletcher  ;  Nichola Johnson  ;  Mervi Grip  ;  Robert Winqvist  ;  Carl Blomqvist  ;  Heli Nevanlinna  ;  Annika Lindblom  ;  Camilla Wendt  ;  Vessela N Kristensen  ;  Rob A E M Tollenaar  ;  Bernadette A M Heemskerk-Gerritsen  ;  Paolo Radice  ;  Bernardo Bonanni  ;  Ute Hamann  ;  Mehdi Manoochehri  ;  James V Lacey  ;  Maria Elena Martinez  ;  Alison M Dunning  ;  Paul D P Pharoah  ;  Douglas F Easton  ;  Keun-Young Yoo  ;  Daehee Kang 
Citation
 CANCERS, Vol.13(10) : 2370, 2021-05 
Journal Title
CANCERS
Issue Date
2021-05
Keywords
breast cancer ; estrogen ; gene-environment interaction
Abstract
In this study we aim to examine gene-environment interactions (GxEs) between genes involved with estrogen metabolism and environmental factors related to estrogen exposure. GxE analyses were conducted with 1970 Korean breast cancer cases and 2052 controls in the case-control study, the Seoul Breast Cancer Study (SEBCS). A total of 11,555 SNPs from the 137 candidate genes were included in the GxE analyses with eight established environmental factors. A replication test was conducted by using an independent population from the Breast Cancer Association Consortium (BCAC), with 62,485 Europeans and 9047 Asians. The GxE tests were performed by using two-step methods in GxEScan software. Two interactions were found in the SEBCS. The first interaction was shown between rs13035764 of NCOA1 and age at menarche in the GE
2df model (p-2df = 1.2 × 10-3). The age at menarche before 14 years old was associated with the high risk of breast cancer, and the risk was higher when subjects had homozygous minor allele G. The second GxE was shown between rs851998 near ESR1 and height in the GE
2df model (p-2df = 1.1 × 10-4). Height taller than 160 cm was associated with a high risk of breast cancer, and the risk increased when the minor allele was added. The findings were not replicated in the BCAC. These results would suggest specificity in Koreans for breast cancer risk.
Files in This Item:
T202104151.pdf Download
DOI
10.3390/cancers13102370
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185453
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links