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Effect of Dexmedetomidine on Biochemical Recurrence in Patients after Robot-Assisted Laparoscopic Radical Prostatectomy: A Retrospective Study

Authors
 Young Chul Yoo  ;  Won Sik Jang  ;  Ki Jun Kim  ;  Jung Hwa Hong  ;  Sunmo Yang  ;  Na Young Kim 
Citation
 JOURNAL OF PERSONALIZED MEDICINE, Vol.11(9) : 912, 2021-09 
Journal Title
JOURNAL OF PERSONALIZED MEDICINE
Issue Date
2021-09
Keywords
biochemical recurrence ; dexmedetomidine ; prostate cancer ; radiographic progression
Abstract
The usage of dexmedetomidine during cancer surgery in current clinical practice is debatable, largely owing to the differing reports of its efficacy based on cancer type. This study aimed to investigate the effects of dexmedetomidine on biochemical recurrence (BCR) and radiographic progression in patients with prostate cancer, who have undergone robot-assisted laparoscopic radical prostatectomy (RALP). Using follow-up data from two prospective randomized controlled studies, BCR and radiographic progression were compared between individuals who received dexmedetomidine (n = 58) and those who received saline (n = 56). Patients with complete follow-up records between July 2013 and June 2019 were enrolled in this study. There were no significant between-group differences in the number of patients who developed BCR and those who showed positive radiographic progression. Based on the Cox regression analysis, age (p = 0.015), Gleason score ≥ 8 (p < 0.001), and pathological tumor stage 3a and 3b (both p < 0.001) were shown to be significant predictors of post-RALP BCR. However, there was no impact on the dexmedetomidine or control groups. Low-dose administration of dexmedetomidine at a rate of 0.3-0.4 μg/kg/h did not significantly affect BCR incidence following RALP. In addition, no beneficial effect was noted on radiographic progression.
Files in This Item:
T202104064.pdf Download
DOI
10.3390/jpm11090912
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ki Jun(김기준) ORCID logo https://orcid.org/0000-0003-1950-7998
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0003-3685-2005
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Jang, Won Sik(장원식) ORCID logo https://orcid.org/0000-0002-9082-0381
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185405
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