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Comparison of the Clinical Features and Outcomes of Gallbladder Neuroendocrine Carcinoma with Those of Adenocarcinoma: A Propensity Score-Matched Analysis

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dc.contributor.author이동기-
dc.contributor.author장성일-
dc.contributor.author조재희-
dc.contributor.author도민영-
dc.contributor.author박고은-
dc.date.accessioned2021-10-21T00:09:09Z-
dc.date.available2021-10-21T00:09:09Z-
dc.date.issued2021-09-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/185399-
dc.description.abstractNeuroendocrine neoplasms (NENs) of the gallbladder (GB) are extremely rare. We aimed to compare the clinical features, disease progression, management, and prognosis of patients with GB-NENs with those of patients with GB-adenocarcinomas (ADCs). A total of 21 patients with GB-NENs and 206 patients with GB-ADCs, treated at three tertiary medical centers between January 2010 and December 2020, were enrolled. Of the 21 patients with GB-NENs, 20 were diagnosed with poorly differentiated small-cell neuroendocrine carcinomas (NECs), and 1 patient had large-cell NEC. All patients presented with advanced stages of cancer with extensive local extension and/or distant metastasis and non-specific symptoms. Tumor-node-metastasis stage IIIB and IV (A/B) tumors were found in 6 and 15 (1/14) patients, respectively. Nine patients with GB-NEC who underwent surgical resection had a significantly better progression-free survival (PFS) than those who did not undergo surgery. After a propensity score matching with a 1:1 ratio using the American Joint Committee on Cancer stage, age, sex, and operation status, 19 pairs of patients were included. Compared with stage-matched patients with GB-ADC, patients with GB-NEC had similar overall survival and PFS. However, as GB-NEC is rarely diagnosed early, further studies investigating methods for the early diagnosis and improvement in the survival of patients with GB-NEC are needed.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfCANCERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleComparison of the Clinical Features and Outcomes of Gallbladder Neuroendocrine Carcinoma with Those of Adenocarcinoma: A Propensity Score-Matched Analysis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMin-Young Do-
dc.contributor.googleauthorSung-Ill Jang-
dc.contributor.googleauthorHua-Pyong Kang-
dc.contributor.googleauthorEui-Joo Kim-
dc.contributor.googleauthorKyong-Joo Lee-
dc.contributor.googleauthorGo-Eun Park-
dc.contributor.googleauthorSu-Jee Lee-
dc.contributor.googleauthorDong-Ki Lee-
dc.contributor.googleauthorSang-Myung Woo-
dc.contributor.googleauthorJae-Hee Cho-
dc.identifier.doi10.3390/cancers13184713-
dc.contributor.localIdA02723-
dc.contributor.localIdA03441-
dc.contributor.localIdA03902-
dc.relation.journalcodeJ03449-
dc.identifier.eissn2072-6694-
dc.identifier.pmid34572940-
dc.subject.keywordadenocarcinoma-
dc.subject.keywordgallbladder-
dc.subject.keywordneuroendocrine carcinoma-
dc.subject.keywordneuroendocrine neoplasm-
dc.subject.keywordpropensity score matching-
dc.contributor.alternativeNameLee, Dong Ki-
dc.contributor.affiliatedAuthor이동기-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor조재희-
dc.citation.volume13-
dc.citation.number18-
dc.citation.startPage4713-
dc.identifier.bibliographicCitationCANCERS, Vol.13(18) : 4713, 2021-09-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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