Cited 4 times in
Comparison of the Clinical Features and Outcomes of Gallbladder Neuroendocrine Carcinoma with Those of Adenocarcinoma: A Propensity Score-Matched Analysis
DC Field | Value | Language |
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dc.contributor.author | 이동기 | - |
dc.contributor.author | 장성일 | - |
dc.contributor.author | 조재희 | - |
dc.contributor.author | 도민영 | - |
dc.contributor.author | 박고은 | - |
dc.date.accessioned | 2021-10-21T00:09:09Z | - |
dc.date.available | 2021-10-21T00:09:09Z | - |
dc.date.issued | 2021-09 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/185399 | - |
dc.description.abstract | Neuroendocrine neoplasms (NENs) of the gallbladder (GB) are extremely rare. We aimed to compare the clinical features, disease progression, management, and prognosis of patients with GB-NENs with those of patients with GB-adenocarcinomas (ADCs). A total of 21 patients with GB-NENs and 206 patients with GB-ADCs, treated at three tertiary medical centers between January 2010 and December 2020, were enrolled. Of the 21 patients with GB-NENs, 20 were diagnosed with poorly differentiated small-cell neuroendocrine carcinomas (NECs), and 1 patient had large-cell NEC. All patients presented with advanced stages of cancer with extensive local extension and/or distant metastasis and non-specific symptoms. Tumor-node-metastasis stage IIIB and IV (A/B) tumors were found in 6 and 15 (1/14) patients, respectively. Nine patients with GB-NEC who underwent surgical resection had a significantly better progression-free survival (PFS) than those who did not undergo surgery. After a propensity score matching with a 1:1 ratio using the American Joint Committee on Cancer stage, age, sex, and operation status, 19 pairs of patients were included. Compared with stage-matched patients with GB-ADC, patients with GB-NEC had similar overall survival and PFS. However, as GB-NEC is rarely diagnosed early, further studies investigating methods for the early diagnosis and improvement in the survival of patients with GB-NEC are needed. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | CANCERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Comparison of the Clinical Features and Outcomes of Gallbladder Neuroendocrine Carcinoma with Those of Adenocarcinoma: A Propensity Score-Matched Analysis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Min-Young Do | - |
dc.contributor.googleauthor | Sung-Ill Jang | - |
dc.contributor.googleauthor | Hua-Pyong Kang | - |
dc.contributor.googleauthor | Eui-Joo Kim | - |
dc.contributor.googleauthor | Kyong-Joo Lee | - |
dc.contributor.googleauthor | Go-Eun Park | - |
dc.contributor.googleauthor | Su-Jee Lee | - |
dc.contributor.googleauthor | Dong-Ki Lee | - |
dc.contributor.googleauthor | Sang-Myung Woo | - |
dc.contributor.googleauthor | Jae-Hee Cho | - |
dc.identifier.doi | 10.3390/cancers13184713 | - |
dc.contributor.localId | A02723 | - |
dc.contributor.localId | A03441 | - |
dc.contributor.localId | A03902 | - |
dc.relation.journalcode | J03449 | - |
dc.identifier.eissn | 2072-6694 | - |
dc.identifier.pmid | 34572940 | - |
dc.subject.keyword | adenocarcinoma | - |
dc.subject.keyword | gallbladder | - |
dc.subject.keyword | neuroendocrine carcinoma | - |
dc.subject.keyword | neuroendocrine neoplasm | - |
dc.subject.keyword | propensity score matching | - |
dc.contributor.alternativeName | Lee, Dong Ki | - |
dc.contributor.affiliatedAuthor | 이동기 | - |
dc.contributor.affiliatedAuthor | 장성일 | - |
dc.contributor.affiliatedAuthor | 조재희 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 18 | - |
dc.citation.startPage | 4713 | - |
dc.identifier.bibliographicCitation | CANCERS, Vol.13(18) : 4713, 2021-09 | - |
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