92 288

Cited 0 times in

Long term outcomes of ruthenium-106 brachytherapy for choroidal melanoma in Korean patients

Other Titles
 한국인에서 Ruthenium-106 근접방사선치료 후 맥락막 흑색종의 장기 예후 
Authors
 최성희 
College
 College of Medicine (의과대학) 
Department
 Dept. of Ophthalmology (안과학교실) 
Degree
석사
Issue Date
2021-02
Abstract
Purpose: The purpose of this study was to report long-term outcomes of ruthenium-106 (106Ru) brachytherapy for choroidal melanoma in Korean patients. Methods: A retrospective review was conducted of 155 consecutive patients that underwent 106Ru brachytherapy for uveal melanoma from 2006 to 2017 with a follow-up period of over 3 years. Baseline clinical characteristics and prognostic indicators such as rates of survival, local recurrence, metastasis, and loss of useful visual acuity (VA) were investigated. Additional analysis was done to determine whether there were any predictive factors for prognosis. Results: The median follow-up was 68 months after brachytherapy. The estimated five-year survival rate was 85.5%, metastasis-free rate was 79.7%, eye preservation rate was 79.7%, and the rate of recurrence-free disease was 86.1%. The rate of losing useful VA (to below 20/200) was 54.6% at 5 years. Initial apical height, radiation dose to the optic nerve and incidence of retinal detachment were found to significantly correlate with loss of VA. Additional local tumor resection did not influence prognosis in very large tumors with apical heights over 8mm. Conclusion: Medium-sized choroidal melanomas show favorable response to 106Ru brachytherapy and additional local treatment does not seem to influence prognosis.

목적: 맥락막 흑색종 환자에서 Ruthenium-106 근접방사선치료 후 장기 예후를 연구해보고자 하였다. 방법: 2006년부터 2017년까지, 맥락막 흑색종 진단 하 Ruthenium-106 근접방사선치료를 시행 받은 후 3년 이상의 추적관찰 기간을 가진 155명의 환자들에 대한 후향적 의무기록 분석을 시행하였다. 기본적 임상 정보 및 종양 관련 정보를 조사하였으며, 사망률, 재발률, 전이율, 실명율 등 예후를 분석하였다. 결과: 환자들의 추적관찰 기간의 중앙값은 68개월이었다. 5년 생존률은 85.5%, 전이없는 생존률은 79.7%, 안구 보존률은 79.7%, 재발 없는 생존률은 54.6%였다. 5년째 시력이 0.1 이하로 떨어지는 기능적 실명률은 54.6% 였다. 기능적 실명의 예측인자로는 높은 치료 전 종양의 높이, 시신경에 대한 큰 방사선 조사량, 망막박리 발생이 있었다. 크기가 큰 종양에서도 경동공 온열치료나 국소적 절제법을 추가하여도 예후의 차이가 없었다. 결론: 한국인에서 중간 크기의 포도막 흑색종은 Ruthenium-106 근접방사선치료에 반응을 잘 하며, 추가적인 국소 치료는 예후에 영향이 적은것으로 보인다.
Files in This Item:
TA02867.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 2. Thesis
Yonsei Authors
Choi, Seonghee(최성희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185354
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links