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Two Photon Fluorescence Microscopy of the Unstained Human Cochlea Reveals Organ of Corti Cytoarchitecture

Authors
 Janani S Iyer  ;  Richard Seist  ;  In Seok Moon  ;  Konstantina M Stankovic 
Citation
 FRONTIERS IN CELLULAR NEUROSCIENCE, Vol.15 : 690953, 2021-08 
Journal Title
FRONTIERS IN CELLULAR NEUROSCIENCE
Issue Date
2021-08
Keywords
cochlear neurons ; hair cells ; human cochlea ; organ of Corti ; two photon fluorescence microscopy
Abstract
Sensorineural hearing loss (SNHL) is the most common sensory deficit worldwide, and it typically originates from the cochlea. Methods to visualize intracochlear cells in living people are currently lacking, limiting not only diagnostics but also therapies for SNHL. Two-photon fluorescence microscopy (TPFM) is a high-resolution optical imaging technique. Here we demonstrate that TPFM enables visualization of sensory cells and auditory nerve fibers in an unstained, non-decalcified adult human cochlea.
Files in This Item:
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DOI
10.3389/fncel.2021.690953
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Moon, In Seok(문인석) ORCID logo https://orcid.org/0000-0002-3951-5074
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/185111
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