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Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

 Suk Kyun Hong  ;  Nam-Joon Yi  ;  Kyung Chul Yoon  ;  Myoung Soo Kim  ;  Jae Geun Lee  ;  Sanghoon Lee  ;  Koo Jeong Kang  ;  Shin Hwang  ;  Je Ho Ryu  ;  Kwangpyo Hong  ;  Eui Soo Han  ;  Jeong-Moo Lee  ;  Kwang-Woong Lee  ;  Kyung-Suk Suh 
 JOURNAL OF CLINICAL MEDICINE, Vol.9(11) : 3435, 2020-10 
Journal Title
Issue Date
complication ; graft survival ; pediatric liver transplantation ; survival
Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY).

Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed.

Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database.

Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Chung, Kyung Young(정경영)
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