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Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

Authors
 Suk Kyun Hong  ;  Nam-Joon Yi  ;  Kyung Chul Yoon  ;  Myoung Soo Kim  ;  Jae Geun Lee  ;  Sanghoon Lee  ;  Koo Jeong Kang  ;  Shin Hwang  ;  Je Ho Ryu  ;  Kwangpyo Hong  ;  Eui Soo Han  ;  Jeong-Moo Lee  ;  Kwang-Woong Lee  ;  Kyung-Suk Suh 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.9(11) : 3435, 2020-10 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2020-10
Keywords
complication ; graft survival ; pediatric liver transplantation ; survival
Abstract
Background: This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY).

Methods: Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed.

Results: The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database.

Conclusion: Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.
Files in This Item:
T999202225.pdf Download
DOI
10.3390/jcm9113435
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Soo(김명수) ORCID logo https://orcid.org/0000-0002-8975-8381
Chung, Kyung Young(정경영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184960
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