Cited 85 times in
High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
DC Field | Value | Language |
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dc.contributor.author | 이덕철 | - |
dc.date.accessioned | 2021-09-29T02:29:26Z | - |
dc.date.available | 2021-09-29T02:29:26Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1931-3128 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184932 | - |
dc.description.abstract | The clinical spectra of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with the greatest risk for pre-IBD. Exposing mice to these risk factors resulted in conditions resembling pre-IBD and impaired mitochondrial bioenergetics in the colonic epithelium, which triggered dysbiosis. Restoring mitochondrial bioenergetics in the colonic epithelium with 5-amino salicylic acid, a PPAR-γ (peroxisome proliferator-activated receptor gamma) agonist that stimulates mitochondrial activity, ameliorated pre-IBD symptoms. As with patients, mice with pre-IBD exhibited notable expansions of Enterobacteriaceae that exacerbated low-grade mucosal inflammation, suggesting that remediating dysbiosis can alleviate inflammation. Thus, environmental risk factors cooperate to impair epithelial mitochondrial bioenergetics, thereby triggering microbiota disruptions that exacerbate inflammation and distinguish pre-IBD from IBS. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Cell Press | - |
dc.relation.isPartOf | CELL HOST & MICROBE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Anti-Bacterial Agents / adverse effects* | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal / therapeutic use | - |
dc.subject.MESH | Diet, High-Fat / adverse effects* | - |
dc.subject.MESH | Dysbiosis / chemically induced | - |
dc.subject.MESH | Dysbiosis / pathology* | - |
dc.subject.MESH | Energy Metabolism / physiology* | - |
dc.subject.MESH | Enterobacteriaceae / growth & development | - |
dc.subject.MESH | Gastrointestinal Microbiome | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Inflammatory Bowel Diseases / microbiology* | - |
dc.subject.MESH | Intestinal Mucosa / microbiology | - |
dc.subject.MESH | Intestinal Mucosa / pathology | - |
dc.subject.MESH | Irritable Bowel Syndrome / microbiology* | - |
dc.subject.MESH | Leukocyte L1 Antigen Complex / metabolism | - |
dc.subject.MESH | Mesalamine / therapeutic use | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mitochondria / metabolism | - |
dc.subject.MESH | PPAR gamma / agonists | - |
dc.title | High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Jee-Yon Lee | - |
dc.contributor.googleauthor | Stephanie A Cevallos | - |
dc.contributor.googleauthor | Mariana X Byndloss | - |
dc.contributor.googleauthor | Connor R Tiffany | - |
dc.contributor.googleauthor | Erin E Olsan | - |
dc.contributor.googleauthor | Brian P Butler | - |
dc.contributor.googleauthor | Briana M Young | - |
dc.contributor.googleauthor | Andrew W L Rogers | - |
dc.contributor.googleauthor | Henry Nguyen | - |
dc.contributor.googleauthor | Kyongchol Kim | - |
dc.contributor.googleauthor | Sang-Woon Choi | - |
dc.contributor.googleauthor | Eunsoo Bae | - |
dc.contributor.googleauthor | Je Hee Lee | - |
dc.contributor.googleauthor | Ui-Gi Min | - |
dc.contributor.googleauthor | Duk-Chul Lee | - |
dc.contributor.googleauthor | Andreas J Bäumler | - |
dc.identifier.doi | 10.1016/j.chom.2020.06.001 | - |
dc.contributor.localId | A02716 | - |
dc.contributor.localId | A05595 | - |
dc.contributor.localId | A02211 | - |
dc.contributor.localId | A01227 | - |
dc.relation.journalcode | J00484 | - |
dc.identifier.eissn | 1934-6069 | - |
dc.identifier.pmid | 32668218 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1931312820303036 | - |
dc.subject.keyword | antibiotics | - |
dc.subject.keyword | dysbiosis | - |
dc.subject.keyword | high-fat diet | - |
dc.subject.keyword | inflammatory bowel disease | - |
dc.subject.keyword | irritable bowel syndrome | - |
dc.subject.keyword | microbiota | - |
dc.contributor.alternativeName | Lee, Duk Chul | - |
dc.contributor.affiliatedAuthor | 이덕철 | - |
dc.citation.volume | 28 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 273 | - |
dc.citation.endPage | 284.e6 | - |
dc.identifier.bibliographicCitation | CELL HOST & MICROBE, Vol.28(2) : 273-284.e6, 2020-08 | - |
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