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Epidemiology of Kawasaki Disease in South Korea: A Nationwide Survey 2015-2017

 Gi Beom Kim  ;  Lucy Youngmin Eun  ;  Ji Whan Han  ;  Sung Hye Kim  ;  Kyung Lim Yoon  ;  Mi Young Han  ;  Jeong Jin Yu  ;  Jong-Woon Choi  ;  Jung Woo Rhim 
 PEDIATRIC INFECTIOUS DISEASE JOURNAL, Vol.39(11) : 1012-1016, 2020-11 
Journal Title
Issue Date
Adolescent ; Child ; Child, Preschool ; Coronary Aneurysm / epidemiology ; Coronary Aneurysm / etiology ; Female ; Humans ; Immunoglobulins, Intravenous / therapeutic use ; Incidence ; Infant ; Infant, Newborn ; Male ; Mucocutaneous Lymph Node Syndrome / complications ; Mucocutaneous Lymph Node Syndrome / drug therapy ; Mucocutaneous Lymph Node Syndrome / epidemiology* ; Republic of Korea / epidemiology ; Surveys and Questionnaires
Background: This study aimed to investigate recent epidemiologic features of Kawasaki disease (KD) in South Korea.

Methods: The ninth triennial nationwide questionnaire survey collected data on the demographic findings, symptoms and signs, treatment patterns and coronary artery complications of acute-phase KD occurred in 2015-2017 from 98 hospitals with pediatric residency programs and 108 community hospitals without residency programs.

Results: We received data from 93 of the 98 hospitals (response rate: 94.9%) with residency programs and 75 of the 108 community-based children's hospitals (response rate: 69.4%) without residency programs. In the 3-year survey period, a total of 15,378 (5449 in 2015, 5171 in 2016 and 4758 in 2017) cases of KD were reported. The mean age at diagnosis was 33.0 ± 24.8 months (range: 0-205 months), and the male-to-female ratio was 1.41:1. The overall KD incidence was 196.9 (202.2 in 2015, 197.1 in 2016 and 191.0 in 2017) per 100,000 younger than 5 years population. Recurrent cases were 4.85%. KD occurred more frequently during winter (December-January) and late spring (May-June). Intravenous immunoglobulin (IVIG) was administered to 95% of the patients; nonresponder rate for the first IVIG was 14.8%. Coronary artery aneurysms and giant coronary artery aneurysms (internal diameter >8 mm) occurred in 1.7% and 19 patients, respectively. Two patients died due to multiorgan failure and hepatic encephalopathy.

Conclusion: Peak incidence of KD in South Korea was 202.2 per 100,000 younger than 5 years population (2015), and the incidence of giant coronary artery aneurysm decreased to 0.09% (2017).
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Eun, Lucy Youngmin(은영민) ORCID logo https://orcid.org/0000-0002-4577-3168
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