0 30

Cited 0 times in

Neuropsychiatric symptoms and striatal monoamine availability in early Parkinson's disease without dementia

Authors
 Yoon-Sang Oh  ;  Jean Hee Kim  ;  Sang-Won Yoo  ;  Eo-Jin Hwang  ;  Chul Hyoung Lyoo  ;  Kwang-Soo Lee  ;  Joong-Seok Kim 
Citation
 NEUROLOGICAL SCIENCES, Vol.42(2) : 711-718, 2021-02 
Journal Title
NEUROLOGICAL SCIENCES
ISSN
 1590-1874 
Issue Date
2021-02
MeSH
Corpus Striatum / diagnostic imaging ; Dementia* ; Humans ; Parkinson Disease* / complications ; Parkinson Disease* / diagnostic imaging ; Positron-Emission Tomography ; Thalamus
Keywords
Monoamine transporter availability ; Neuropsychiatric symptoms ; Parkinson’s disease
Abstract
Background and objective: Neuropsychiatric symptoms are relatively common in Parkinson's disease (PD). Many studies have revealed that striatal monoamine availability is associated with specific neuropsychiatric symptoms. This study was aimed to investigate the association between comprehensive neuropsychiatric symptoms and striatal monoamine availability in patients with early PD without dementia. Methods: A total of 156 newly diagnosed patients with PD without dementia were included. All patients' mental and behavioral problems were assessed with the 12-item Neuropsychiatric Inventory (NPI). They underwent positron emission tomography (PET) with 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane and brain magnetic resonance imaging (MRI). Patients were divided into no neuropsychiatric symptoms and neuropsychiatric symptoms groups according to total NPI score. After normalizing the PET images to spatially normalized MRI, regional standardized uptake value ratios (SUVRs) with a volume of interest template were analyzed for the two groups. Results: Ninety-eight patients had more than one neuropsychiatric symptom. The SUVR of the thalamus in neuropsychiatric symptoms group was significantly lower than the SUVR in no neuropsychiatric symptoms group independent of age, sex, disease duration, or severity of motor symptoms. Conclusion: Patients with early PD who have neuropsychiatric symptoms had a lower monoamine availability in the thalamus than those with no neuropsychiatric symptoms. This finding suggests that decreased monoamine transporter availability in the thalamus may be an imaging biomarker of neuropsychiatric symptoms in patients with PD.
Full Text
https://link.springer.com/article/10.1007%2Fs10072-020-04859-8
DOI
10.1007/s10072-020-04859-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184828
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links