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Synergistic Effect of 300 μm Needle-Depth Fractional Microneedling Radiofrequency on the Treatment of Senescence-Induced Aging Hyperpigmentation of the Skin

DC Field Value Language
dc.contributor.author김제민-
dc.contributor.author김지희-
dc.contributor.author이동원-
dc.contributor.author이영인-
dc.contributor.author이원재-
dc.contributor.author이주희-
dc.date.accessioned2021-09-29T02:17:33Z-
dc.date.available2021-09-29T02:17:33Z-
dc.date.issued2021-07-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184811-
dc.description.abstractAging-associated dermatological pigmentary diseases are associated with accumulation of senescence cells and the disruption of basement membrane due to chronic ultraviolet radiation (UVR) exposure. Our study is on the synergistic effect of the novel 300 μm needle-depth fractional microneedling radiofrequency (FMR) treatment and conventional Q-switched ND:YAG laser on aging-associated hyperpigmentation of the skin. The prospective controlled clinical trial of 25 Asian women revealed significantly higher improvements not only on wrinkles, but also on hyperpigmentation. Additional ex vivo study revealed significant reduction of pro-melanogenic markers as well as senescent keratinocytes, while increased expression of collagen type IV on the epidermal basement membrane, after additional FMR treatment on UV-irradiated human tissues. These results demonstrate that 300 μm needle-depth FMR might effectively remove senescent keratinocytes that secrete pro-melanogenic markers, and repair disrupted basement membrane, therefore preventing constant hyperpigmentation of the aged skin.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHCellular Senescence*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHHyperpigmentation / etiology-
dc.subject.MESHHyperpigmentation / pathology-
dc.subject.MESHHyperpigmentation / radiotherapy*-
dc.subject.MESHLasers, Solid-State / therapeutic use*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHSkin / radiation effects*-
dc.subject.MESHSkin Aging / radiation effects*-
dc.subject.MESHUltraviolet Rays / adverse effects*-
dc.titleSynergistic Effect of 300 μm Needle-Depth Fractional Microneedling Radiofrequency on the Treatment of Senescence-Induced Aging Hyperpigmentation of the Skin-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Dermatology (피부과학교실)-
dc.contributor.googleauthorYoung In Lee-
dc.contributor.googleauthorEunbin Kim-
dc.contributor.googleauthorDong Won Lee-
dc.contributor.googleauthorJemin Kim-
dc.contributor.googleauthorJihee Kim-
dc.contributor.googleauthorWon Jai Lee-
dc.contributor.googleauthorJu Hee Lee-
dc.identifier.doi10.3390/ijms22147480-
dc.contributor.localIdA05725-
dc.contributor.localIdA04732-
dc.contributor.localIdA02729-
dc.contributor.localIdA05880-
dc.contributor.localIdA03005-
dc.contributor.localIdA03171-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid34299100-
dc.subject.keywordNd:YAG laser-
dc.subject.keywordfractional microneedling radiofrequency-
dc.subject.keywordlentigo-
dc.subject.keywordmelasma-
dc.subject.keywordsenescence-
dc.subject.keywordultraviolet B-
dc.contributor.alternativeNameKim, Jemin-
dc.contributor.affiliatedAuthor김제민-
dc.contributor.affiliatedAuthor김지희-
dc.contributor.affiliatedAuthor이동원-
dc.contributor.affiliatedAuthor이영인-
dc.contributor.affiliatedAuthor이원재-
dc.contributor.affiliatedAuthor이주희-
dc.citation.volume22-
dc.citation.number14-
dc.citation.startPage7480-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(14) : 7480, 2021-07-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Plastic and Reconstructive Surgery (성형외과학교실) > 1. Journal Papers

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