0 205

Cited 0 times in

Excitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice

DC Field Value Language
dc.contributor.author이은이-
dc.date.accessioned2021-09-29T02:17:02Z-
dc.date.available2021-09-29T02:17:02Z-
dc.date.issued2021-08-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184807-
dc.description.abstractNMDA receptor (NMDAR) and GABA neuronal dysfunctions are observed in animal models of autism spectrum disorders, but how these dysfunctions impair social cognition and behavior remains unclear. We report here that NMDARs in cortical parvalbumin (Pv)-positive interneurons cooperate with gap junctions to promote high-frequency (>80 Hz) Pv neuronal burst firing and social cognition. Shank2-/- mice, displaying improved sociability upon NMDAR activation, show impaired cortical social representation and inhibitory neuronal burst firing. Cortical Shank2-/- Pv neurons show decreased NMDAR activity, which suppresses the cooperation between NMDARs and gap junctions (GJs) for normal burst firing. Shank2-/- Pv neurons show compensatory increases in GJ activity that are not sufficient for social rescue. However, optogenetic boosting of Pv neuronal bursts, requiring GJs, rescues cortical social cognition in Shank2-/- mice, similar to the NMDAR-dependent social rescue. Therefore, NMDARs and gap junctions cooperate to promote cortical Pv neuronal bursts and social cognition.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleExcitatory synapses and gap junctions cooperate to improve Pv neuronal burst firing and cortical social cognition in Shank2-mutant mice-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorEunee Lee-
dc.contributor.googleauthorSeungjoon Lee-
dc.contributor.googleauthorJae Jin Shin-
dc.contributor.googleauthorWoochul Choi-
dc.contributor.googleauthorChanguk Chung-
dc.contributor.googleauthorSuho Lee-
dc.contributor.googleauthorJihye Kim-
dc.contributor.googleauthorSeungmin Ha-
dc.contributor.googleauthorRyunhee Kim-
dc.contributor.googleauthorTaesun Yoo-
dc.contributor.googleauthorYe-Eun Yoo-
dc.contributor.googleauthorJisoo Kim-
dc.contributor.googleauthorYoung Woo Noh-
dc.contributor.googleauthorIssac Rhim-
dc.contributor.googleauthorSoo Yeon Lee-
dc.contributor.googleauthorWoohyun Kim-
dc.contributor.googleauthorTaekyung Lee-
dc.contributor.googleauthorHyogeun Shin-
dc.contributor.googleauthorIl-Joo Cho-
dc.contributor.googleauthorKarl Deisseroth-
dc.contributor.googleauthorSang Jeong Kim-
dc.contributor.googleauthorJoo Min Park-
dc.contributor.googleauthorMin Whan Jung-
dc.contributor.googleauthorSe-Bum Paik-
dc.contributor.googleauthorEunjoon Kim-
dc.identifier.doi10.1038/s41467-021-25356-2-
dc.contributor.localIdA06099-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid34433814-
dc.identifier.urlhttps://www.nature.com/articles/s41467-021-25356-2-
dc.contributor.alternativeNameLee, Eunee-
dc.contributor.affiliatedAuthor이은이-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPage5116-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.12(1) : 5116, 2021-08-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.