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Comparison of Postoperative Pain and Adverse Effects between Variable-Rate Feedback Infusion and Conventional Fixed-Rate Basal Infusion Modes of Patient-Controlled Epidural Analgesia following Open Gastrectomy: A Randomized Controlled Trial

Authors
 Yoo Kyung Jang  ;  Na Young Kim  ;  Jeong Soo Lee  ;  Hye Jung Shin  ;  Hyoung Gyun Kim  ;  Suk Woo Lee  ;  Jae Chul Koh  ;  Young Chul Yoo 
Citation
 INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, Vol.18(16) : 8777, 2021-08 
Journal Title
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
ISSN
 1661-7827 
Issue Date
2021-08
MeSH
Amides ; Analgesia, Epidural* ; Analgesics, Opioid / therapeutic use ; Anesthetics, Local ; Feedback ; Fentanyl ; Gastrectomy / adverse effects ; Humans ; Pain, Postoperative / drug therapy ; Pain, Postoperative / prevention & control ; Prospective Studies ; Ropivacaine
Keywords
background infusion ; open gastrectomy ; patient-controlled epidural analgesia ; postoperative nausea ; postoperative pain
Abstract
Patient-controlled epidural analgesia is widely used to control postoperative pain following major intra-abdominal surgeries. However, determining the optimal infusion dose that can produce effective analgesia while reducing side effects remains a task to be solved. Postoperative pain and adverse effects between variable-rate feedback infusion (VFIM group, n = 36) and conventional fixed-rate basal infusion (CFIM group, n = 36) of fentanyl/ropivacaine-based patient-controlled epidural analgesia were evaluated. In the CFIM group, the basal infusion rate was fixed (5 mL/h), whereas, in the VFIM group, the basal infusion rate was increased by 0.5 mL/h each time a bolus dose was administered and decreased by 0.3 mL/h when a bolus dose was not administered for 2 h. Patients in the VFIM group experienced significantly less pain at one to six hours after surgery than those in the CFIM group. Further, the number of patients who suffered from postoperative nausea was significantly lower in the VFIM group than in the CFIM group until six hours after surgery. The variable-rate feedback infusion mode of patient-controlled epidural analgesia may provide better analgesia accompanied with significantly less nausea in the early postoperative period than the conventional fixed-rate basal infusion mode following open gastrectomy.
Files in This Item:
T202103675.pdf Download
DOI
10.3390/ijerph18168777
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Koh, Jae Chul(고재철)
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0003-3685-2005
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
Lee, Jeong Soo(이정수) ORCID logo https://orcid.org/0000-0002-8947-3706
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184792
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