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De Novo Cancer Incidence after Kidney Transplantation in South Korea from 2002 to 2017

Authors
 Boyeon Kim  ;  Minjin Kang  ;  Yoonjung Kim  ;  Hyung Soon Lee  ;  Banseok Kim  ;  Jung Jun Lee  ;  Yongjung Park  ;  Kyung-A Lee 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.10(16) : 3530, 2021-08 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2021-08
Keywords
kidney transplantation ; malignancy ; cancer risk ; population-based study
Abstract
Advances in patient care and immunosuppressive drugs have improved graft survival, resulting in an increase in kidney transplantation (KT); however, persistent immunosuppression is thought to cause late occurrence of cancer. This population-based study consisted of a total of 14,842 patients whose data from the years 2002 to 2017 were collected from the National Health Information Database in South Korea. Malignancies occurred in 7.6% of the total KT patients. Prostate and thyroid cancers were the most common in males and females, respectively. From the age-adjusted incidence analysis, Kaposi’s sarcoma showed the highest standardized incidence ratio in both male and female patients. According to the linear regression model, cancer incidence in KT recipients under immunosuppressive conditions increased by approximately 0.1% each month. Patients’ age over 39 and the use of prednisolone as an initial steroid regimen were associated with increased risk of cancer development after KT. Our regression and proportional hazards models will help clinicians to predict the approximate cancer incidence risk when monitoring KT recipients. Based on the largest available national database, screening or monitoring methods for cancer detection and prevention can be established for KT patients by considering the factors involved in cancer development.
DOI
10.3390/jcm10163530
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Boyeon(김보연)
Kim, Yoon Jung(김윤정) ORCID logo https://orcid.org/0000-0002-4370-4265
Park, Yong Jung(박용정) ORCID logo https://orcid.org/0000-0001-5668-4120
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
Lee, Jung Jun(이정준)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184738
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