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Improvement of Osseointegration by Ultraviolet and/or Simvastatin Treatment on Titanium Implants with or without Bone Graft Materials

 Ji Hoon Jun  ;  Kyung Chul Oh  ;  Kyu-Hyung Park  ;  Narae Jung  ;  Jiayi Li  ;  Hong Seok Moon 
 MATERIALS, Vol.14(13) : 3707, 2021-07 
Journal Title
Issue Date
animal experiments ; bone implant interactions ; bone regeneration ; bone substitutes ; illumination ; statin ; titanium
We evaluated and compared ultraviolet (UV) treatment and simvastatin (SIM) immersion effects on the osseointegration of sandblasted, large-grit, acid-etched (SLA) titanium dental implants at two different time points in rabbit tibias, with or without xenogenic bone graft materials. The surface alteration on simvastatin treatment titanium discs was analyzed using an infrared spectrometer. Implants were categorized into four groups according to the surface treatment type. Twelve rabbits received two implants per tibia. A tibial defect model was created using a trephine bur, with implants in contact with the bone surface and bovine bone graft materials for gap filling. The rabbits were sacrificed after 2 or 4 weeks. UV treatment or SIM immersion increased the bone-to-implant contact (BIC) on nongrafted sides, and both increased the BIC and bone area (BA) on grafted sides. The application of both treatments did not result in higher BIC or BA than a single treatment. At two different time points, BIC in the nongrafted sides did not differ significantly among the UV and/or SIM treated groups, whereas BA differed significantly. UV or SIM treatment of SLA titanium implants accelerates osseointegration in tibias with or without xenogenic bone graft materials. The combination of both treatments did not show synergy.
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2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Oh, Kyung Chul(오경철) ORCID logo https://orcid.org/0000-0003-4584-2597
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