Surgical-orthodontic treatment for severe malocclusion in a patient with osteopetrosis and bilateral cleft lip and palate

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MeSH: Adult ; Cleft Lip* / complications ; Cleft Lip* / diagnostic imaging ; Cleft Lip* / surgery ; Cleft Palate* / complications ; Cleft Palate* / diagnostic imaging ; Cleft Palate* / surgery ; Esthetics, Dental ; Female ; Humans ; Malocclusion* / diagnostic imaging ; Malocclusion* / therapy ; Osteopetrosis* / complications ; Osteopetrosis* / diagnostic imaging ; Osteopetrosis* / therapy ; Young Adult

Keywords: Bone turnover marker ; Malocclusion ; Orthognathic surgery ; Osteopetrosis ; Surgical-orthodontic treatment

Abstract: Orthognathic surgery in patients with craniofacial osteopetrosis, a condition associated with osteoclast dysfunction, is usually avoided because of the risk of osteomyelitis. A 19-year-old woman presented with the chief complaint of severe malocclusion and anterior crossbite. After radiographic evaluation, craniofacial osteopetrosis was diagnosed. Surgical-orthodontic treatment was performed after meticulous history taking and verification of normal bone turnover using bone-metabolism markers for endocrine evaluation. Favorable esthetic and functional outcomes were achieved.