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Overexpression of poliovirus receptor is associated with poor prognosis in head and neck squamous cell carcinoma patients

Authors
 Sun Min Lim  ;  Min Hee Hong  ;  Sang-Jun Ha  ;  Daehee Hwang  ;  Sehyun Chae  ;  Yoon Woo Koh  ;  Eun Chang Choi  ;  Se-Heon Kim  ;  Da-Hee Kim  ;  Sun Och Yoon  ;  Hye Ryun Kim 
Citation
 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.147(9) : 2741-2750, 2021-09 
Journal Title
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
ISSN
 0171-5216 
Issue Date
2021-09
MeSH
Aged ; B7-H1 Antigen / metabolism* ; Biomarkers, Tumor / metabolism* ; Female ; Follow-Up Studies ; Head and Neck Neoplasms / metabolism ; Head and Neck Neoplasms / pathology* ; Head and Neck Neoplasms / surgery ; Humans ; Male ; Prognosis ; Receptors, Virus / metabolism* ; Retrospective Studies ; Squamous Cell Carcinoma of Head and Neck / metabolism ; Squamous Cell Carcinoma of Head and Neck / pathology* ; Squamous Cell Carcinoma of Head and Neck / surgery ; Surgical Procedures, Operative / mortality* ; Survival Rate
Keywords
Biomarkers ; Poliovirus receptor ; Programmed death-ligand ; Squamous cell carcinoma of head and neck
Abstract
Purpose: We aimed to investigate the prognostic value of multiple immune cell markers including programmed death-ligand 1 (PD-L1) and poliovirus receptor (PVR) in head and neck squamous cell carcinoma (HNSCC) using archival tumor tissues METHODS: Patients diagnosed with HNSCC who have undergone surgical resection in 2005-2012 were included. Correlations between PVR and PD-L1 expression and patient characteristics were analyzed by analysis of variance. The Kaplan-Meier method and log-rank test were used to estimate survival. P values < 0.05 were considered statistically significant.

Results: In total, 375 primary tumor tissues were analyzed using immunohistochemistry. High PVR expression was associated with a poor prognosis in terms of overall survival (OS) and recurrence-free survival (RFS), and tumors with high PVR expression were associated with a short OS. PD-L1 tumor expression did not have a prognostic impact on survival. Univariate analysis revealed that OS and RFS were affected by age and p16 and PVR expression; multivariate analysis revealed that age and p16 and PVR expression were the most important determinants of RFS.

Conclusion: PVR overexpression is a poor prognostic factor in patients with HNSCC and co-targeting PVR and PD-L1 may be a promising therapeutic option that needs further investigation.
Full Text
https://link.springer.com/article/10.1007%2Fs00432-021-03531-8
DOI
10.1007/s00432-021-03531-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Kim, Da Hee(김다희) ORCID logo https://orcid.org/0000-0001-7286-1334
Kim, Se Heon(김세헌)
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Yoon, Sun Och(윤선옥) ORCID logo https://orcid.org/0000-0002-5115-1402
Lim, Sun Min(임선민)
Choi, Eun Chang(최은창)
Hong, Min Hee(홍민희) ORCID logo https://orcid.org/0000-0003-3490-2195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184617
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