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The promise of bispecific antibodies: Clinical applications and challenges

Authors
 Sun Min Lim  ;  Kyoung-Ho Pyo  ;  Ross A Soo  ;  Byoung Chul Cho 
Citation
 CANCER TREATMENT REVIEWS, Vol.99 : 102240, 2021-09 
Journal Title
CANCER TREATMENT REVIEWS
ISSN
 0305-7372 
Issue Date
2021-09
MeSH
Antibodies, Bispecific / immunology ; Antibodies, Bispecific / therapeutic use* ; Antineoplastic Agents, Immunological / therapeutic use ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Clinical Trials, Phase III as Topic ; Humans ; Immune Checkpoint Inhibitors / therapeutic use ; Neoplasms / immunology* ; Neoplasms / therapy* ; Randomized Controlled Trials as Topic
Keywords
Bispecific antibodies ; Cancer
Abstract
The development of cancer therapies using monoclonal antibodies has been successful during the last 30 years. Recently much progress was achieved with technologies involving bispecific and multi-specific antibodies. Bispecific antibodies (BsAbs) are antibodies that bind two distinct epitopes, and a large number of potential clinical applications of BsAbs have been described. Here we review mechanism of action, clinical development and future challenges of BsAbs which could be a serve as a valuable arsenal in cancer patients.
Full Text
https://www.sciencedirect.com/science/article/pii/S0305737221000888
DOI
10.1016/j.ctrv.2021.102240
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lim, Sun Min(임선민)
Cho, Byoung Chul(조병철) ORCID logo https://orcid.org/0000-0002-5562-270X
Pyo, Kyoung Ho(표경호) ORCID logo https://orcid.org/0000-0001-5428-0288
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184588
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