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3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects in Materials

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dc.contributor.author박진영-
dc.contributor.author백정원-
dc.contributor.author차재국-
dc.contributor.author최성호-
dc.date.accessioned2021-09-29T01:49:49Z-
dc.date.available2021-09-29T01:49:49Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184569-
dc.description.abstractBackground: Polycarprolactone and beta tricalcium phosphate (PCL/β-TCP) are resorbable biomaterials that exhibit ideal mechanical properties as well as high affinity for osteogenic cells. Aim: Objective of this study was to evaluate healing and tissue reaction to the PCL/β-TCP barrier membrane in the rabbit calvaria model for guided bone regeneration. Materials and methods: The PCL/β-TCP membranes were 3D printed. Three circular defects were created in calvaria of 10 rabbits. The three groups were randomly allocated for each specimen: (i) sham control; (ii) PCL/β-TCP membrane (PCL group); and (iii) PCL/β-TCP membrane with synthetic bone graft (PCL-BG group). The animals were euthanized after two (n = 5) and eight weeks (n = 5) for volumetric and histomorphometric analyses. Results: The greatest augmented volume was achieved by the PCL-BG group at both two and eight weeks (p < 0.01). There was a significant increase in new bone after eight weeks in the PCL group (p = 0.04). The PCL/β-TCP membrane remained intact after eight weeks with slight degradation, and showed good tissue integration. Conclusions: PCL/β-TCP membrane exhibited good biocompatibility, slow degradation, and ability to maintain space over eight weeks. The 3D-printed PCL/β-TCP membrane is a promising biomaterial that could be utilized for reconstruction of critical sized defects.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.title3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects in Materials-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontics (치주과학교실)-
dc.contributor.googleauthorJun-Young Lee-
dc.contributor.googleauthorJin-Young Park-
dc.contributor.googleauthorIn-Pyo Hong-
dc.contributor.googleauthorSu-Hee Jeon-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorJeong-Won Paik-
dc.contributor.googleauthorSeong-Ho Choi-
dc.identifier.doi10.3390/ma14123280-
dc.contributor.localIdA04749-
dc.contributor.localIdA01836-
dc.contributor.localIdA04004-
dc.contributor.localIdA04081-
dc.relation.journalcodeJ02182-
dc.identifier.eissn1996-1944-
dc.identifier.pmid34198549-
dc.subject.keyword3D printing-
dc.subject.keywordbeta tricalcium phosphate-
dc.subject.keywordguided bone regeneration-
dc.subject.keywordmembrane-
dc.subject.keywordpolycarprolactone-
dc.contributor.alternativeNamePark, Jin Young-
dc.contributor.affiliatedAuthor박진영-
dc.contributor.affiliatedAuthor백정원-
dc.contributor.affiliatedAuthor차재국-
dc.contributor.affiliatedAuthor최성호-
dc.citation.volume14-
dc.citation.number12-
dc.citation.startPage3280-
dc.identifier.bibliographicCitationMATERIALS, Vol.14(12) : 3280, 2021-06-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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