Cited 17 times in
Club cell-specific role of programmed cell death 5 in pulmonary fibrosis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김경원 | - |
dc.contributor.author | 김미정 | - |
dc.contributor.author | 김수연 | - |
dc.contributor.author | 박무석 | - |
dc.contributor.author | 박수연 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 심효섭 | - |
dc.contributor.author | 윤호근 | - |
dc.contributor.author | 이수연 | - |
dc.contributor.author | 이승현 | - |
dc.contributor.author | 홍정연 | - |
dc.date.accessioned | 2021-09-29T01:43:58Z | - |
dc.date.available | 2021-09-29T01:43:58Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184522 | - |
dc.description.abstract | Idiopathic pulmonary fibrosis (IPF) causes progressive fibrosis and worsening pulmonary function. Prognosis is poor and no effective therapies exist. We show that programmed cell death 5 (PDCD5) expression is increased in the lungs of patients with IPF and in mouse models of lung fibrosis. Lung fibrosis is significantly diminished by club cell-specific deletion of Pdcd5 gene. PDCD5 mediates β-catenin/Smad3 complex formation, promoting TGF-β-induced transcriptional activation of matricellular genes. Club cell Pdcd5 knockdown reduces matricellular protein secretion, inhibiting fibroblast proliferation and collagen synthesis. Here, we demonstrate the club cell-specific role of PDCD5 as a mediator of lung fibrosis and potential therapeutic target for IPF. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Apoptosis Regulatory Proteins / deficiency | - |
dc.subject.MESH | Apoptosis Regulatory Proteins / genetics* | - |
dc.subject.MESH | Apoptosis Regulatory Proteins / metabolism | - |
dc.subject.MESH | Bronchioles / metabolism | - |
dc.subject.MESH | Bronchioles / pathology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Epithelial Cells / metabolism | - |
dc.subject.MESH | Epithelial Cells / pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression | - |
dc.subject.MESH | Gene Knockdown Techniques | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis / genetics* | - |
dc.subject.MESH | Idiopathic Pulmonary Fibrosis / pathology* | - |
dc.subject.MESH | Lung / metabolism | - |
dc.subject.MESH | Lung / pathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred C57BL | - |
dc.subject.MESH | Mice, Knockout | - |
dc.subject.MESH | Mice, Transgenic | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Proteins / deficiency | - |
dc.subject.MESH | Neoplasm Proteins / genetics* | - |
dc.subject.MESH | Neoplasm Proteins / metabolism | - |
dc.subject.MESH | Respiratory Mucosa / metabolism | - |
dc.subject.MESH | Respiratory Mucosa / pathology | - |
dc.subject.MESH | Signal Transduction | - |
dc.subject.MESH | Smad3 Protein / metabolism | - |
dc.subject.MESH | Transforming Growth Factor beta / metabolism | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases / metabolism | - |
dc.title | Club cell-specific role of programmed cell death 5 in pulmonary fibrosis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Soo-Yeon Park | - |
dc.contributor.googleauthor | Jung Yeon Hong | - |
dc.contributor.googleauthor | Soo Yeon Lee | - |
dc.contributor.googleauthor | Seung-Hyun Lee | - |
dc.contributor.googleauthor | Mi Jeong Kim | - |
dc.contributor.googleauthor | Soo Yeon Kim | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.contributor.googleauthor | Hyo Sup Shim | - |
dc.contributor.googleauthor | Moo Suk Park | - |
dc.contributor.googleauthor | Chun Geun Lee | - |
dc.contributor.googleauthor | Jack A Elias | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Ho-Geun Yoon | - |
dc.identifier.doi | 10.1038/s41467-021-23277-8 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00450 | - |
dc.contributor.localId | A04724 | - |
dc.contributor.localId | A01457 | - |
dc.contributor.localId | A01534 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A02219 | - |
dc.contributor.localId | A02625 | - |
dc.contributor.localId | A06054 | - |
dc.contributor.localId | A02932 | - |
dc.contributor.localId | A04431 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 34011956 | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | 김경원 | - |
dc.contributor.affiliatedAuthor | 김미정 | - |
dc.contributor.affiliatedAuthor | 김수연 | - |
dc.contributor.affiliatedAuthor | 박무석 | - |
dc.contributor.affiliatedAuthor | 박수연 | - |
dc.contributor.affiliatedAuthor | 손명현 | - |
dc.contributor.affiliatedAuthor | 심효섭 | - |
dc.contributor.affiliatedAuthor | 윤호근 | - |
dc.contributor.affiliatedAuthor | 이수연 | - |
dc.contributor.affiliatedAuthor | 이승현 | - |
dc.contributor.affiliatedAuthor | 홍정연 | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 2923 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.12(1) : 2923, 2021-05 | - |
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