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Effect of antimicrobial photodynamic therapy with Chlorella and Curcuma extract on Streptococcus mutans biofilms

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dc.contributor.author김백일-
dc.contributor.author이은송-
dc.contributor.author강시묵-
dc.date.accessioned2021-09-29T01:39:22Z-
dc.date.available2021-09-29T01:39:22Z-
dc.date.issued2021-07-
dc.identifier.issn1572-1000-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184478-
dc.description.abstractBackground: Antimicrobial photodynamic therapy (aPDT) using natural photosensitive agents is an effective method for preventing oral diseases of bacterial origin. The purpose of this study was to evaluate the antimicrobial effect of aPDT, using powdered extracts of Chlorella and Curcuma, on the biofilms of Streptococcus mutans (S. mutans), a bacterium that is known to cause dental caries. Methods: Commercially available powdered Chlorella and Curcuma extracts were used as photosensitizers. S. mutans, cultured for 2 days, was inoculated (0.1 ml; 1 × 109 CFU/ml) on the surface of a hydroxyapatite (HA) disc and incubated for 24 h to allow the formation of a biofilm. The HA disc with the S. mutans biofilm was immersed in either Curcuma extract (0.5 mg/ml), Chlorella extract, distilled water (negative control), or Listerine (positive control) for 1 min and then irradiated with an LED (Qraycam; wavelength, 405 nm; energy, 59 mW) for 5 min. Results: The application of aPDT with Curcuma or Chlorella extract to S. mutans 24-hour biofilms significantly decreased the number of viable cells and the live/dead cell ratio when compared with those in the negative control (distilled water; p < 0.05). Conclusions: aPDT using 405 nm light and Chlorella or Curcuma as a photosensitizer has significant antimicrobial effects against S. mutans biofilms. Thus, employing aPDT with natural plant extracts as photosensitizers could be an effective strategy for preventing dental caries but needs to be evaluated in properly controlled clinical trials..-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfPHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of antimicrobial photodynamic therapy with Chlorella and Curcuma extract on Streptococcus mutans biofilms-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Preventive Dentistry and Public Oral Health (예방치과학교실)-
dc.contributor.googleauthorHye-Rim Hwang-
dc.contributor.googleauthorEun-Song Lee-
dc.contributor.googleauthorSi-Mook Kang-
dc.contributor.googleauthorKi-Ho Chung-
dc.contributor.googleauthorBaek-Il Kim-
dc.identifier.doi10.1016/j.pdpdt.2021.102411-
dc.contributor.localIdA00485-
dc.contributor.localIdA04635-
dc.relation.journalcodeJ02519-
dc.identifier.eissn1873-1597-
dc.identifier.pmid34147697-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1572100021002386-
dc.subject.keywordAntibacterial photodynamic therapy-
dc.subject.keywordBiofilm-
dc.subject.keywordDental caries-
dc.subject.keywordNatural photosensitizer-
dc.subject.keywordStreptococcus mutans-
dc.contributor.alternativeNameKim, Baek Il-
dc.contributor.affiliatedAuthor김백일-
dc.contributor.affiliatedAuthor이은송-
dc.citation.volume35-
dc.citation.startPage102411-
dc.identifier.bibliographicCitationPHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, Vol.35 : 102411, 2021-07-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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