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The role of PTPN22 in the pathogenesis of autoimmune diseases: A comprehensive review

Authors
 Kalthoum Tizaoui  ;  Salvatore Terrazzino  ;  Sarah Cargnin  ;  Keum Hwa Lee  ;  Philipp Gauckler  ;  Han Li  ;  Jae Il Shin  ;  Andreas Kronbichler 
Citation
 SEMINARS IN ARTHRITIS AND RHEUMATISM, Vol.51(3) : 513-522, 2021-06 
Journal Title
SEMINARS IN ARTHRITIS AND RHEUMATISM
ISSN
 0049-0172 
Issue Date
2021-06
Keywords
Autoimmune diseases ; Immune cells ; LYP protein ; Mouse models ; Protein tyrosine phosphatase non-receptor 22 (PTPN22)
Abstract
The incidence of autoimmune diseases is increasing worldwide, thus stimulating studies on their etiopathogenesis, derived from a complex interaction between genetic and environmental factors. Genetic association studies have shown the PTPN22 gene as a shared genetic risk factor with implications in multiple autoimmune disorders. By encoding a protein tyrosine phosphatase expressed by the majority of cells belonging to the innate and adaptive immune systems, the PTPN22 gene may have a fundamental role in the development of immune dysfunction. PTPN22 polymorphisms are associated with rheumatoid arthritis, type 1 diabetes, systemic lupus erythematosus, and many other autoimmune conditions. In this review, we discuss the progress in our understanding of how PTPN22 impacts autoimmunity in both humans and animal models. In addition, we highlight the pathogenic significance of the PTPN22 gene, with particular emphasis on its role in T and B cells, and its function in innate immune cells, such as monocytes, dendritic and natural killer cells. We focus particularly on the complexity of PTPN22 interplay with biological processes of the immune system. Findings highlight the importance of studying the function of disease-associated PTPN22 variants in different cell types and open new avenues of investigation with the potential to drive further insights into mechanisms of PTPN22. These new insights will reveal important clues to the molecular mechanisms of prevalent autoimmune diseases and propose new potential therapeutic targets.
Full Text
https://www.sciencedirect.com/science/article/pii/S0049017221000342
DOI
10.1016/j.semarthrit.2021.03.004
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184473
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