Cited 9 times in
Predicting allergic diseases in children using genome-wide association study (GWAS) data and family history
DC Field | Value | Language |
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dc.contributor.author | 김경원 | - |
dc.contributor.author | 김미나 | - |
dc.contributor.author | 김윤희 | - |
dc.contributor.author | 손명현 | - |
dc.contributor.author | 홍정연 | - |
dc.date.accessioned | 2021-09-29T01:38:09Z | - |
dc.date.available | 2021-09-29T01:38:09Z | - |
dc.date.issued | 2021-05 | - |
dc.identifier.issn | * | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/184471 | - |
dc.description.abstract | The recent rise in the prevalence of chronic allergic diseases among children has increased disease burden and reduced quality of life, especially for children with comorbid allergic diseases. Predicting the occurrence of allergic diseases can help prevent its onset for those in high risk groups. Herein, we aimed to construct prediction models for asthma, atopic dermatitis (AD), and asthma-AD comorbidity (also known as atopic march) using a genome-wide association study (GWAS) and family history data from patients of Korean heritage. Among 973 patients and 481 healthy controls, we evaluated single nucleotide polymorphism (SNP) heritability for each disease using genome-based restricted maximum likelihood (GREML) analysis. We then compared the performance of prediction models constructed using Least Absolute Shrinkage and Selection Operator (LASSO) and penalized ridge regression methods. Our results indicate that the addition of family history risk scores to the prediction model greatly increase the predictability of asthma and asthma-AD comorbidity. However, prediction of AD was mostly attributable to GWAS SNPs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Elsevier Inc. | - |
dc.relation.isPartOf | WORLD ALLERGY ORGANIZATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Predicting allergic diseases in children using genome-wide association study (GWAS) data and family history | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아과학교실) | - |
dc.contributor.googleauthor | Jaehyun Park | - |
dc.contributor.googleauthor | Haerin Jang | - |
dc.contributor.googleauthor | Mina Kim | - |
dc.contributor.googleauthor | Jung Yeon Hong | - |
dc.contributor.googleauthor | Yoon Hee Kim | - |
dc.contributor.googleauthor | Myung Hyun Sohn | - |
dc.contributor.googleauthor | Sang-Cheol Park | - |
dc.contributor.googleauthor | Sungho Won | - |
dc.contributor.googleauthor | Kyung Won Kim | - |
dc.identifier.doi | 10.1016/j.waojou.2021.100539 | - |
dc.contributor.localId | A00303 | - |
dc.contributor.localId | A00441 | - |
dc.contributor.localId | A00799 | - |
dc.contributor.localId | A01967 | - |
dc.contributor.localId | A04431 | - |
dc.relation.journalcode | J03985 | - |
dc.identifier.eissn | 1939-4551 | - |
dc.identifier.pmid | 34035874 | - |
dc.subject.keyword | Asthma | - |
dc.subject.keyword | Atopic dermatitis | - |
dc.subject.keyword | Family history | - |
dc.subject.keyword | Genome-wide association study | - |
dc.subject.keyword | Prediction model | - |
dc.contributor.alternativeName | Kim, Kyung Won | - |
dc.contributor.affiliatedAuthor | 김경원 | - |
dc.contributor.affiliatedAuthor | 김미나 | - |
dc.contributor.affiliatedAuthor | 김윤희 | - |
dc.contributor.affiliatedAuthor | 손명현 | - |
dc.contributor.affiliatedAuthor | 홍정연 | - |
dc.citation.volume | 14 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 100539 | - |
dc.identifier.bibliographicCitation | WORLD ALLERGY ORGANIZATION JOURNAL, Vol.14(5) : 100539, 2021-05 | - |
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