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Androgen-deprivation therapy and the risk of newly developed fractures in patients with prostate cancer: a nationwide cohort study in Korea

DC Field Value Language
dc.contributor.author이혜선-
dc.contributor.author조강수-
dc.contributor.author하지수-
dc.contributor.author조강수-
dc.contributor.author하지수-
dc.date.accessioned2021-09-29T01:31:39Z-
dc.date.available2021-09-29T01:31:39Z-
dc.date.issued2021-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184413-
dc.description.abstractWe evaluated the risk of osteoporosis and fractures associated with androgen deprivation therapy (ADT) use and duration in men with prostate cancer. From the nationwide claims database in South Korea, a total of 218,203 men with prostate cancer were identified between 2008 and 2017. After applying the inclusion and exclusion criteria, a total of 144,670 patients were included in the analysis. To adjust for comorbidities between cohorts, 1:1 propensity score matching was used. Cox proportional hazard regression models were used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of events associated with ADT, after controlling for potential confounding factors. In the matched cohort, there were differences in the incidence of newly developed osteoporosis (8.79% in the ADT group vs. 7.08% in the non-ADT group, p < 0.0001) and fractures (8.12% in the ADT group vs. 5.04% in the non-ADT group, p < 0.0001). Age-adjusted Cox regression analysis revealed that the ADT group had a significantly higher risk of osteoporosis (HR, 1.381; 95% CI, 1.305-1.461; p < 0.0001) and fractures (HR, 1.815; 95% CI, 1.703-1.935; p < 0.0001) compared to the non-ADT group. Furthermore, the risk of osteoporosis and fractures increased as the duration of ADT increased. The ADT was associated with an increased risk of osteoporosis and fractures in prostate cancer patients. Clinicians who administer ADT for patients with prostate cancer should always be mindful of the risk of osteoporosis and fracture, avoid unnecessary ADT, and perform regular bone health check-ups.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAndrogen-deprivation therapy and the risk of newly developed fractures in patients with prostate cancer: a nationwide cohort study in Korea-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentYonsei Biomedical Research Center (연세의생명연구원)-
dc.contributor.googleauthorDo Kyung Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJu-Young Park-
dc.contributor.googleauthorJong Won Kim-
dc.contributor.googleauthorHyun Kyu Ahn-
dc.contributor.googleauthorJee Soo Ha-
dc.contributor.googleauthorKang Su Cho-
dc.identifier.doi10.1038/s41598-021-89589-3-
dc.contributor.localIdA03312-
dc.contributor.localIdA03801-
dc.contributor.localIdA05527-
dc.contributor.localIdA03801-
dc.contributor.localIdA05527-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid33980958-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor조강수-
dc.contributor.affiliatedAuthor하지수-
dc.contributor.affiliatedAuthor조강수-
dc.contributor.affiliatedAuthor하지수-
dc.citation.volume11-
dc.citation.number1-
dc.citation.startPage10057-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.11(1) : 10057, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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