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Association of Serum Alkaline Phosphatase with the TG/HDL Ratio and TyG Index in Korean Adults

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dc.contributor.author손다혜-
dc.contributor.author이용제-
dc.contributor.author하현수-
dc.date.accessioned2021-09-29T01:30:54Z-
dc.date.available2021-09-29T01:30:54Z-
dc.date.issued2021-06-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184406-
dc.description.abstractAlkaline phosphatase (ALP) has long been considered a marker of hepatobiliary and bone disorders, but recent studies have shown that increased ALP activity is correlated with various cardio-metabolic diseases. Thus, we investigated the association of serum ALP level with surrogate markers of insulin resistance such as triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C ratio) and triglyceride and glucose (TyG) index in the general population. The study included 12,868 men and women aged 19 years and older. Participants were categorized into four groups based on serum ALP level (U/L) as follows: Q1: 55-190 U/L, Q2: 191-224 U/L, Q3: 225-265 U/L, and Q4: 266-923 U/L for men, Q1: 48-161 U/L, Q2: 162-198 U/L, Q3: 199-245 U/L, Q4: 246-790 U/L for women. The insulin resistance cut-off levels were defined corresponding to the 75th percentile of the TyG index and TG/HDL-C ratio in the current samples. Odds ratios (ORs) with 95% confidence intervals (CIs) of insulin resistance according to quartile of serum ALP level were calculated using weighted multivariate logistic regression analysis. Compared with Q1, the adjusted OR (95% CI) for insulin resistance of the Q4 serum ALP group was 1.517 (1.234-1.866) in men and 1.881 (1.399-2.528) in women using the TG/HDL-C ratio and 1.374 (1.093-1.728) in men and 2.047 (1.468-2.855) in women using the TyG index after adjusting for confounding variables. Serum ALP levels are independently and positively associated with surrogate markers of insulin resistance in Korean adults.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfBIOMOLECULES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleAssociation of Serum Alkaline Phosphatase with the TG/HDL Ratio and TyG Index in Korean Adults-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorDa-Hye Son-
dc.contributor.googleauthorHyun-Su Ha-
dc.contributor.googleauthorYong-Jae Lee-
dc.identifier.doi10.3390/biom11060882-
dc.contributor.localIdA05543-
dc.contributor.localIdA02982-
dc.contributor.localIdA06113-
dc.relation.journalcodeJ03712-
dc.identifier.eissn2218-273X-
dc.identifier.pmid34198561-
dc.subject.keywordalkaline phosphatase-
dc.subject.keywordinsulin resistance-
dc.subject.keywordtriglyceride and glucose index-
dc.subject.keywordtriglyceride to high-density lipoprotein cholesterol ratio-
dc.contributor.alternativeNameSon, Da‐Hye-
dc.contributor.affiliatedAuthor손다혜-
dc.contributor.affiliatedAuthor이용제-
dc.contributor.affiliatedAuthor하현수-
dc.citation.volume11-
dc.citation.number6-
dc.citation.startPage882-
dc.identifier.bibliographicCitationBIOMOLECULES, Vol.11(6) : 882, 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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