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Risk and protective factors for cannabis, cocaine, and opioid use disorders: An umbrella review of meta-analyses of observational studies

Authors
 Marco Solmi  ;  Elena Dragioti  ;  Giovanni Croatto  ;  Joaquim Radua  ;  Stefan Borgwardt  ;  Andrè F Carvalho  ;  Jacopo Demurtas  ;  Anna Mosina  ;  Peter Konstantin Kurotschka  ;  Jae Il Shin  ;  Paolo Fusar-Poli 
Citation
 NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol.126 : 243-251, 2021-07 
Journal Title
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
ISSN
 0149-7634 
Issue Date
2021-07
MeSH
Cannabis* / adverse effects ; Cocaine* ; Humans ; Meta-Analysis as Topic ; Observational Studies as Topic ; Opioid-Related Disorders* / epidemiology ; Protective Factors ; Risk Factors
Keywords
Cannabis ; Cocaine ; Mental health ; Meta-analysis ; Opioid ; Prevention ; Risk factor ; Systematic review ; Umbrella review
Abstract
Several meta-analyses of observational studies have addressed the association between risk and protective factors and cannabis/cocaine/opioid use disorders, but results are conflicting. No umbrella review has ever graded the credibility of this evidence (not significant/weak/suggestive/highly suggestive/convincing). We searched Pubmed-MEDLINE/PsycInfo, last search September 21, 2020. We assessed the quality of meta-analyses with the AMSTAR-2 tool. Out of 3,072 initial references, five were included, providing 19 associations between 12 putative risk/protective factors and cannabis/cocaine/opioid use disorders (cases: 4539; N = 1,118,872,721). While 84 % of the associations were statistically significant, none was convincing. One risk factor (smoking) had highly suggestive evidence for association with nonmedical use of prescription opioid medicines (OR = 3.07, 95 %CI:2.27 to 4.14). Convincing evidence emerged in sensitivity analyses on antisocial behavior and cannabis use disoder (OR 3.34, 95 %CI 2.53-4.41). Remaining associations had weak evidence. The quality of meta-analyses was rated as moderate in two (40 %), low in one (20 %), and critically low in two (40 %). Future research is needed to better profile risk/protective factors for cannabis/cocaine/opioid use disorders disorders informing preventive approaches.
Full Text
https://www.sciencedirect.com/science/article/pii/S0149763421001275
DOI
10.1016/j.neubiorev.2021.03.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184398
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