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Coronary calcification is associated with elevated serum lipoprotein (a) levels in asymptomatic men over the age of 45 years: A cross-sectional study of the Korean national health checkup data

Authors
 Young Hak Chung  ;  Byoung-Kwon Lee  ;  Hyuck Moon Kwon  ;  Pil-Ki Min  ;  Eui-Young Choi  ;  Young Won Yoon  ;  Bum-Kee Hong  ;  Se-Joong Rim  ;  Jong-Youn Kim 
Citation
 MEDICINE, Vol.100(9) : e24,962, 2021-03 
Journal Title
MEDICINE
ISSN
 0025-7974 
Issue Date
2021-03
MeSH
Asymptomatic Diseases ; Biomarkers / blood ; Coronary Angiography ; Coronary Artery Disease / blood* ; Coronary Artery Disease / epidemiology ; Coronary Vessels / diagnostic imaging* ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Humans ; Incidence ; Lipoprotein(a) / blood* ; Male ; Mass Screening / methods* ; Middle Aged ; Prognosis ; Republic of Korea / epidemiology ; Retrospective Studies ; Risk Factors ; Vascular Calcification / blood* ; Vascular Calcification / epidemiology
Abstract
Lipoprotein a (Lp (a)) and coronary artery calcification (CAC) are markers of coronary artery and cardiovascular diseases. However, the association between Lp (a) and CAC in asymptomatic individuals remains unclear. In this study, we aimed to determine the influence of Lp (a) on CAC in asymptomatic individuals.We included 2019 asymptomatic Korean adults who underwent testing for a coronary artery calcium score (CACS) and Lp (a) at the Gangnam Severance Hospital Health Checkup Center in Korea from January 2017 to August 2019. Participants were divided into 2 groups: CACS = 0 and CACS > 0. Factors affecting the CACS were analyzed by sex. Because age is a major risk factor for atherosclerosis, ≥45 years in men and ≥55 years in women, we further divided participants into 4 subgroups (≥45 and <45 in men, ≥55 and <55 in women). Factors affecting the CACS in the 4 groups were analyzed.There was a positive correlation between the CACS and traditional cardiovascular risk factors. Lp (a) positively correlated with the CACS in men (P < .01) and remained significant after multivariable logistic regression (P < .01). The same result was observed in men aged ≥45 years (P < .01).Lp (a) is an independently associated factor of CAC and a marker of coronary atherosclerosis in asymptomatic men aged ≥45 years. In asymptomatic men aged ≥45 years, Lp (a) should be measured, and intensive Lp (a)-lowering treatment should be considered.
Files in This Item:
T202102953.pdf Download
DOI
10.1097/MD.0000000000024962
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Moon(권혁문) ORCID logo https://orcid.org/0000-0001-9901-5015
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Min, Pil Ki(민필기) ORCID logo https://orcid.org/0000-0001-7033-7651
Yoon, Young Won(윤영원) ORCID logo https://orcid.org/0000-0002-0907-0350
Lee, Byoung Kwon(이병권) ORCID logo https://orcid.org/0000-0001-9259-2776
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Chung, Young Hak(정영학)
Choi, Eui Young(최의영) ORCID logo https://orcid.org/0000-0003-3732-0190
Hong, Bum Kee(홍범기) ORCID logo https://orcid.org/0000-0002-6456-0184
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184389
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