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From nonalcoholic fatty liver disease to metabolic-associated fatty liver disease: Big wave or ripple?

Authors
 Seong Hee Kang  ;  Yuri Cho  ;  Soung Won Jeong  ;  Seung Up Kim  ;  Jin-Woo Lee 
Citation
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.27(2) : 257-269, 2021-04 
Journal Title
CLINICAL AND MOLECULAR HEPATOLOGY
ISSN
 2287-2728 
Issue Date
2021-04
Keywords
Diabetes mellitus ; Metabolic (dysfunction)-associated fatty liver disease ; Metabolic syndrome ; Non-alcoholic fatty liver disease ; Outcome
Abstract
There is some dissatisfaction with the term "nonalcoholic fatty liver disease (NAFLD)," which overemphasizes alcohol and underemphasizes the importance of metabolic risk factors in this disease. Recently, a consensus recommended "metabolic (dysfunction)-associated fatty liver disease (MAFLD)" as a more appropriate term to describe fatty liver diseases (FLD) associated with metabolic dysfunction. During the definition change from NAFLD to MAFLD, subjects with FLD and metabolic abnormalities, together with other etiologies of liver diseases such as alcohol, virus, or medication who have been excluded from the NAFLD criteria, were added to the MAFLD criteria, while subjects with FLD but without metabolic abnormality, who have been included in the NAFLD criteria, were excluded from the MAFLD criteria. This means that there is an emphasis on the metabolic dysfunction in MAFLD which may underestimate the prognostic value of hepatic steatosis itself, whereas the MAFLD criteria might better identify subjects who are at a higher risk of hepatic or cardiovascular outcomes. However, non-metabolic risk NAFLD subjects who are excluded from the MAFLD criteria are missed from the diagnosis, and their potential risk can be the cause of future diseases. Although huge controversies remain, this review focused on summarizing recent studies that compared the clinical and prognostic characteristics between subjects with NAFLD and MAFLD.
Files in This Item:
T202102939.pdf Download
DOI
10.3350/cmh.2021.0067
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184378
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