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Acute and chronic effects of vaping electronic devices on lung physiology and inflammation

Authors
 Jorge A Masso-Silva  ;  Min Kwang Byun  ;  Laura E Crotty Alexander 
Citation
 CURRENT OPINION IN PHYSIOLOGY, Vol.22 : 100447, 2021-08 
Journal Title
CURRENT OPINION IN PHYSIOLOGY
ISSN
 2468-8673 
Issue Date
2021-08
Abstract
The impact of e-cigarette use on the inflammatory state and function of the lungs is not well understood. Here we review the latest studies on the impact of short and long term e-cigarette aerosol inhalation on molecular pathways, cellular recruitment, gas exchange and airway physiology. Inflammatory cytokines IL-6 and IL-8 were increased by e-cigarette exposures, and a variety of immune cells were recruited to the parenchyma and airways across models. While there are few consistent signals across in vitro, in vivo and human studies, due to the multitude of different e-devices and the combination of chemicals within different aerosols generated, it is clear that use of e-cigarettes does alter the inflammatory state and function of the lungs with both acute and chronic use. This is evidenced by the multitude of inflammatory lung diseases already tied to e-cigarette use, but the causal chemicals are primarily remain at large.
Full Text
https://www.sciencedirect.com/science/article/pii/S2468867321000729
DOI
10.1016/j.cophys.2021.06.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184360
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