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Dysregulation of HOX as a Potential Therapeutic Target in Breast Cancer

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dc.contributor.author김명희-
dc.contributor.author이지연-
dc.contributor.author이지연-
dc.date.accessioned2021-09-29T01:14:31Z-
dc.date.available2021-09-29T01:14:31Z-
dc.date.issued2021-06-
dc.identifier.issn0929-8673-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/184263-
dc.description.abstractHOX genes belong to the highly conserved homeobox superfamily, responsible for the regulation of various cellular processes that control cell homeostasis, from embryogenesis to carcinogenesis. The abnormal expression of HOX genes is observed in various cancers, including breast cancer; they act as oncogenes or as suppressors of cancer, according to context. In this review, we analyze HOX gene expression patterns in breast cancer and examine their relationship, based on the three-dimensional genome structure of the HOX locus. The presence of non-coding RNAs, embedded within the HOX cluster, and the role of these molecules in breast cancer have been reviewed. We further evaluate the characteristic activity of HOX protein in breast cancer and its therapeutic potential.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBentham Science Publishers-
dc.relation.isPartOfCURRENT MEDICINAL CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDysregulation of HOX as a Potential Therapeutic Target in Breast Cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학교실)-
dc.contributor.googleauthorJi-Yeon Lee-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi10.2174/0929867327666201102115327-
dc.contributor.localIdA00432-
dc.contributor.localIdA03194-
dc.contributor.localIdA03194-
dc.relation.journalcodeJ00668-
dc.identifier.eissn1875-533X-
dc.identifier.pmid33138748-
dc.identifier.urlhttps://www.eurekaselect.com/187426/article-
dc.subject.keywordHOX gene-
dc.subject.keywordHOX cluster-
dc.subject.keywordnon-coding RNA-
dc.subject.keywordgenomic organization-
dc.subject.keyword3D structure-
dc.subject.keywordHOX protein-
dc.subject.keywordbreast cancer-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.affiliatedAuthor김명희-
dc.contributor.affiliatedAuthor이지연-
dc.contributor.affiliatedAuthor이지연-
dc.citation.volume28-
dc.citation.startPageepub.-
dc.identifier.bibliographicCitationCURRENT MEDICINAL CHEMISTRY, Vol.28 : epub., 2021-06-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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