0 178

Cited 0 times in

The long-term risk of lymphoma and skin cancer did not increase after topical calcineurin inhibitor use and phototherapy in a cohort of 25,694 patients with vitiligo

Authors
 Hyun Jeong Ju  ;  Ju Hee Han  ;  Min-Soo Kim  ;  Si-Hyung Lee  ;  Jung-Won Shin  ;  Mira Choi  ;  Ki-Heon Jeong  ;  Tae Young Han  ;  Chong Won Choi  ;  Hee Jung Lee  ;  Sang Ho Oh  ;  Sang Hoon Lee  ;  Dong Hyun Kim  ;  Jeonghyun Shin  ;  Jong Hee Lee  ;  Sang Seok Kim  ;  Hee Young Kang  ;  Sung Eun Chang  ;  Jeong-Soo Kim  ;  Dong-Youn Lee  ;  Gwang Seong Choi  ;  Dae Hun Suh  ;  You Chan Kim  ;  Chul Jong Park  ;  Ki-Ho Kim  ;  Ai-Young Lee  ;  Kyoung Chan Park  ;  Mu-Hyoung Lee  ;  Jung Min Bae 
Citation
 JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, Vol.84(6) : 1619-1627, 2021-06 
Journal Title
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
ISSN
 0190-9622 
Issue Date
2021-06
Keywords
actinic keratosis ; excimer laser ; lymphoma ; melanoma ; narrowband ultraviolet B ; skin cancer ; tacrolimus ; vitiligo
Abstract
Background: Topical calcineurin inhibitors have been used to treat vitiligo, either alone or in combination with phototherapy; however, the long-term safety of these agents remains controversial.

Objective: To investigate the risk of lymphoma and skin cancer in vitiligo patients who received topical calcineurin inhibitors or phototherapy.

Methods: A multicenter retrospective cohort study of 25,694 vitiligo patients who received topical calcineurin inhibitors or phototherapy for 6 weeks or more between 2001 and 2019 was performed. Cumulative doses of topical calcineurin inhibitors and total phototherapy sessions were determined. Outcomes were the development of lymphoma or skin cancer after enrollment, confirmed through chart review and pathology reports.

Results: During 95,203 person-years, 13 cases of lymphoma, 22 of actinic keratosis, 15 of nonmelanoma skin cancer, and 5 of melanoma were observed. The risk of lymphoma and skin cancer was not significantly increased by topical calcineurin inhibitor dose or phototherapy sessions. The interaction between the topical calcineurin inhibitors and phototherapy was not associated with an increased risk of skin cancer.

Limitations: Retrospective study, individual follow-up duration less than 4 years, and no adjustment for comorbidities and medication history. Not generalizable to other races.

Conclusion: The long-term risk of skin cancer or lymphoma was not associated with the use of topical calcineurin inhibitors, phototherapy, and both treatments in combination in patients with vitiligo.
Full Text
https://www.sciencedirect.com/science/article/pii/S0190962221002243
DOI
10.1016/j.jaad.2021.01.067
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Sang Ho(오상호) ORCID logo https://orcid.org/0000-0002-4477-1400
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184141
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links