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The Korean Society for Neuro-Oncology (KSNO) guideline for antiepileptic drug usage of brain tumor: Version 2021.1

 Jangsup Moon  ;  Min Sung Kim  ;  Young Zoon Kim  ;  Kihwan Hwang  ;  Ji Eun Park  ;  Kyung Hwan Kim  ;  Jin Mo Cho  ;  Wan Soo Yoon  ;  Se Hoon Kim  ;  Young Il Kim  ;  Ho Sung Kim  ;  Yun Sik Dho  ;  Jae Sung Park  ;  Hong In Yoon  ;  Youngbeom Seo  ;  Kyoung Su Sung  ;  Jin Ho Song  ;  Chan Woo Wee  ;  Min Ho Lee  ;  Myung Hoon Han  ;  Je Beom Hong  ;  Jung Ho Im  ;  Se Hoon Lee  ;  Jong Hee Chang  ;  Do Hoon Lim  ;  Chul Kee Park  ;  Youn Soo Lee  ;  Ho Shin Gwak 
 Brain Tumor Research and Treatment, Vol.9(1) : 9-15, 2021-04 
Journal Title
Brain Tumor Research and Treatment
Issue Date
Antiepileptic drug ; Brain tumors ; Guideline ; Korean Society for Neuro-Oncology ; Practice
Background: To date, there has been no practical guidelines for the prescription of antiepileptic drugs (AEDs) in brain tumor patients in Korea. Thus, the Korean Society for Neuro-Oncology (KSNO), a multidisciplinary academic society, had begun preparing guidelines for AED usage in brain tumors since 2019.

Methods: The Working Group was composed of 27 multidisciplinary medical experts in Korea. References were identified through searches of PubMed, MEDLINE, EMBASE, and Cochrane CENTRAL using specific and sensitive keywords as well as combinations of the keywords.

Results: The core contents are as follows. Prophylactic AED administration is not recommended in newly diagnosed brain tumor patients without previous seizure history. When AEDs are administered during peri/postoperative period, it may be tapered off according to the following recommendations. In seizure-naïve patients with no postoperative seizure, it is recommended to stop or reduce AED 1 week after surgery. In seizure-naïve patients with one early postoperative seizure (<1 week after surgery), it is advisable to maintain AED for at least 3 months before tapering. In seizure-naïve patients with ≥2 postoperative seizures or in patients with preoperative seizure history, it is recommended to maintain AEDs for more than 1 year. The possibility of drug interactions should be considered when selecting AEDs in brain tumor patients. Driving can be allowed in brain tumor patients when proven to be seizure-free for more than 1 year.

Conclusion: The KSNO suggests prescribing AEDs in patients with brain tumor based on the current guideline. This guideline will contribute to spreading evidence-based prescription of AEDs in brain tumor patients in Korea.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Yoon, Hong In(윤홍인) ORCID logo https://orcid.org/0000-0002-2106-6856
Chang, Jong Hee(장종희) ORCID logo https://orcid.org/0000-0003-1509-9800
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