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High Level of Real Urban Air Pollution Promotes Cardiac Arrhythmia in Healthy Mice

 Hyewon Park  ;  Sangchul Lim  ;  Seunghoon Lee  ;  Dasom Mun  ;  JiYoung Kang  ;  Hyoeun Kim  ;  Hyelim Park  ;  Changsoo Kim  ;  Sunho Park  ;  Yeong Min Lim  ;  Boyoung Joung 
 KOREAN CIRCULATION JOURNAL, Vol.51(2) : 157-170, 2021-02 
Journal Title
Issue Date
Air pollution ; Arrhythmia ; Fibrosis ; Inflammation
Background and objectives: Ambient particulate matter (PM) in real urban air pollution (RUA) is an environmental health risk factor associated with increased cardiac events. This study investigated the threshold level to induce arrhythmia, as well as arrhythmogenic mechanism of RUA that mainly consisted of PM <2.5 μm in aerodynamic diameter close to ultrafine particles.

Methods: RUA was artificially produced by a lately developed pyrolysis based RUA generator. C57BL/6 mice were divided into 4 groups: a control group (control, n=12) and three groups with exposure to RUA with the concentration of 200 μg/m³ (n=12), 400 μg/m³ (n=12), and 800 μg/m³ (n=12). Mice were exposed to RUA at each concentration for 8 hr/day and 5 day/week to mimic ordinary human activity during 3 weeks.

Results: The QRS and QTc intervals, as well as intracellular Ca2+ duration, apicobasal action potential duration (APD) gradient, fibrosis, and inflammation of left ventricle of mouse hearts were increased dose-dependently with the increase of RUA concentration, and significantly increased at RUA concentration of 400 μg/m³ compared to control (all p<0.001). In mice exposed to RUA concentration of 800 μg/m³, spontaneous ventricular arrhythmia was observed in 42%, with significant increase of inflammatory markers, phosphorylated Ca2+/calmodulin-dependent protein kinase II (CaMKII), and phospholamban (PLB) compared to control.

Conclusions: RUA could induce electrophysiological changes such as APD and QT prolongation, fibrosis, and inflammation dose-dependently, with significant increase of ventricular arrhythmia at the concentration of 400 μg/m³. RUA concentration of 800 μg/m³ increased phosphorylation of CaMKII and PLB.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
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