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Association of serum hemoglobin level with the risk of carotid plaque beyond metabolic abnormalities among asymptomatic adults without major adverse clinical events: a cross-sectional cohort study

Authors
 Yunsuk Choi  ;  Ki-Bum Won  ;  Hyeon Hui Kang  ;  Hyuk-Jae Change 
Citation
 BMC CARDIOVASCULAR DISORDERS, Vol.21(1) : 35, 2021-03 
Journal Title
BMC CARDIOVASCULAR DISORDERS
Issue Date
2021-03
MeSH
Aged ; Asymptomatic Diseases ; Biomarkers / blood ; Carotid Artery Diseases / blood* ; Carotid Artery Diseases / diagnostic imaging ; Carotid Artery Diseases / epidemiology ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Female ; Hemoglobins / analysis* ; Humans ; Male ; Metabolic Syndrome / blood* ; Metabolic Syndrome / diagnosis ; Metabolic Syndrome / epidemiology ; Middle Aged ; Plaque, Atherosclerotic* ; Prevalence ; Prognosis ; Risk Assessment ; Risk Factors ; Seoul / epidemiology ; Up-Regulation
Keywords
Atherosclerosis ; Carotid plaque ; Hemoglobin ; Metabolic syndrome
Abstract
Background: The serum hemoglobin (Hb) level is closely related to adverse clinical outcomes. However, data on the association of Hb levels with subclinical atherosclerosis beyond metabolic abnormalities are limited.

Methods: This study evaluated the association among serum Hb level, metabolic syndrome (MetS), and the risk of carotid plaque formation in asymptomatic adults without a history of major adverse clinical events.

Results: A total of 2560 participants (mean age: 60 ± 8 years, 32.9% men) were stratified into four groups based on Hb quartiles, as follows: ≤ 12.8 g/dL (group I), 12.9-13.6 g/dL (group II), 13.7-14.5 g/dL (group III), and ≥ 14.6 g/dL (group IV). The overall prevalence of MetS and carotid plaque was 37.2% and 33.4%, respectively. The prevalence of MetS increased with increasing Hb level (group I: 27.4% vs. group II: 35.9% vs. group III: 42.6% vs. group IV: 44.1%, p < 0.001). The prevalence of carotid plaque was 34.3%, 28.1%, 32.8%, and 39.5% in groups I, II, III, and IV, respectively. Univariate logistic regression analysis showed that MetS was associated with an increased risk of carotid plaque (odds ratio [OR] 1.568, 95% confidence interval [CI] 1.326-1.856, p < 0.001). Only group II showed a lower risk of carotid plaque than group I (OR 0.750, 95% CI 0.596-0.943, p = 0.014). Multiple logistic regression models showed consistent results after adjusting for clinical factors, including MetS and its individual components.

Conclusion: Serum Hb level is associated with the risk of carotid plaque beyond MetS and its components in a relatively healthy adult population.
Files in This Item:
T202102105.pdf Download
DOI
10.1186/s12872-021-01852-7
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Hyuk-Jae(장혁재) ORCID logo https://orcid.org/0000-0002-6139-7545
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184099
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