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Preoperative Routine Laboratory Markers for Predicting Postoperative Recurrence and Death in Patients with Breast Cancer

 Young-Chul Yoo  ;  Seho Park  ;  Hyun-Joo Kim  ;  Hyun-Eom Jung  ;  Ji-Young Kim  ;  Myoung-Hwa Kim 
 JOURNAL OF CLINICAL MEDICINE, Vol.10(12) : 2610, 2021-06 
Journal Title
Issue Date
breast cancer ; cancer antigen 15-3 ; death ; recurrence ; red cell distribution width
Simple, convenient, and reliable preoperative prognostic indicators are needed to estimate the future risk of recurrences and guide the treatment decisions associated with breast cancer. We evaluated preoperative hematological markers related to recurrence and mortality and investigated independent risk factors for recurrence and mortality in patients after breast cancer surgery. We reviewed electronic medical records of patients with invasive breast cancer diagnosed at our tertiary institution between November 2005 and December 2010 and followed them until 2015. We compared two groups of patients classified according to recurrence or death and identified risk factors for postoperative outcomes. Data from 1783 patients were analyzed ultimately. Cancer antigen (CA) 15-3 and red cell distribution width (RDW) had the highest area under the curve values among several preoperative hematological markers for disease-free survival and overall survival (0.590 and 0.637, respectively). Patients with both preoperative CA 15-3 levels over 11.4 and RDW over 13.5 had a 1.7-fold higher risk of recurrence (hazard ratio (HR): 1.655; 95% confidence interval (CI): 1.154-2.374; p = 0.007) and mortality (HR: 1.723; 95% CI: 1.098-2.704; p = 0.019). In conclusion, relatively high preoperative RDW (>13.5) and CA 15-3 levels (>11.4) had the highest predictive power for mortality and recurrence, respectively. When RDW and CA 15-3 exceeded the cut-off value, the risk of recurrence and death also increased approximately 1.7 times.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hwa(김명화) ORCID logo https://orcid.org/0000-0003-4723-9425
Kim, Ji Young(김지영) ORCID logo https://orcid.org/0000-0001-5822-0338
Kim, Hyun Joo(김현주) ORCID logo https://orcid.org/0000-0003-1963-8955
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Yoo, Young Chul(유영철) ORCID logo https://orcid.org/0000-0002-6334-7541
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