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Efficacy and safety of selective internal radiation therapy with yttrium-90 for the treatment of unresectable hepatocellular carcinoma

Authors
 Nguyen Van Thai  ;  Nguyen Tien Thinh  ;  Thai Doan Ky  ;  Mai Hong Bang  ;  Dinh Truong Giang  ;  Le Ngoc Ha  ;  Mai Hong Son  ;  Dao Duc Tien  ;  Hyun Woong Lee 
Citation
 BMC GASTROENTEROLOGY, Vol.21(1) : 216, 2021-05 
Journal Title
BMC GASTROENTEROLOGY
Issue Date
2021-05
MeSH
Aged ; Carcinoma, Hepatocellular* / radiotherapy ; Humans ; Liver Neoplasms* / radiotherapy ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Yttrium Radioisotopes / adverse effects
Keywords
Hepatocellular carcinoma ; Selective internal radiation therapy ; Survival ; Tumor response ; Yttrium-90
Abstract
Background: This retrospective analysis was undertaken to evaluate the efficiency of SIRT with Y-90 microspheres and determined prognostic factors affecting patients with unresectable HCC.

Methods: A total of 97 patients diagnosed with unresectable HCC who underwent SIRT with Y-90 microspheres. Patient survival was assessed using the Kaplan-Meier method, and prognostic factors affecting survival were assessed using log-rank tests and Cox proportional hazards regression.

Results: Among the 97 patients (90 males, mean age 60.4 ± 12.3 years) who underwent SIRT, the median clinical follow-up was 16.4 (1.8-62) months. The median overall survival (OS) was 23.9 ± 2.4 months. Tumor response according to the Modified RECIST in patients followed up beyond 6 months included a complete response (CR) to treatment in 12 patients (18.8%), partial response (PR) in 23 (35.8%), stable disease (SD) in 8 (12.5%), and progressive disease (PD) in 21 (32.8%). Factors associated with longer OS included age > 65 years, BCLC stage B, tumor size < 5 cm, tumor burden < 25%, and tumor response (CR/PR). In multivariate analysis, unilobar disease and objective tumor response (CR/PR) were predictors of longer OS.

Conclusion: SIRT was an effective treatment for unresectable HCC. Unilobar disease before SIRT and tumor response (CR/PR) were positive prognostic factors.
Files in This Item:
T202101976.pdf Download
DOI
10.1186/s12876-021-01805-6
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyun Woong(이현웅) ORCID logo https://orcid.org/0000-0002-6958-3035
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184062
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