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Botulinum Toxin Type-A (Botulax ®) Treatment in Patients with Intractable Chronic Occipital Neuralgia: A Pilot Study

Authors
 Hyeyun Kim  ;  Bongjin Jang  ;  Seong-Taek Kim 
Citation
 TOXINS, Vol.13(5) : 332, 2021-05 
Journal Title
TOXINS
Issue Date
2021-05
MeSH
Adult ; Botulinum Toxins, Type A / administration & dosage* ; Chronic Pain / drug therapy ; Female ; Follow-Up Studies ; Headache / drug therapy* ; Humans ; Male ; Middle Aged ; Neuralgia / drug therapy* ; Neuromuscular Agents / administration & dosage* ; Neuromuscular Agents / adverse effects ; Pilot Projects ; Treatment Outcome
Keywords
botulinum toxin injection ; chronic occipital neuralgia ; greater occipital nerve
Abstract
Intractable chronic occipital neuralgia (ON) is an uncommon type of headache often experienced by patients in outpatient neurological clinics. Among patients unresponsive to oral neuralgia medications, needling or injections with several drugs were suggested alternatives for treating chronic ON. This study aimed to determine the effectiveness and safety of botulinum toxin type-A (BTX-A) injection treatments, where eight patients with unilateral chronic ON received BTX-A injections at the pain sites. The pain relief effect was observed 2 weeks after receiving the injections, gradually showing improvements up to 12 weeks after injection. There were no adverse events or changes from baseline in serologic studies and vital signs in any of the participants. The treatment's pain-relieving effects were confirmed through regular, 12-week follow-ups, confirming the safety and effectiveness of BTX-A on chronic ON and suggesting that this method is an effective, novel alternative option for chronic ON treatment.
DOI
10.3390/toxins13050332
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Orofacial Pain and Oral Medicine (구강내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Taek(김성택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/184000
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