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Cited 3 times in

Effect of Alzheimer's Disease and Lewy Body Disease on Metabolic Changes

DC Field Value Language
dc.contributor.author백경원-
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author윤미진-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author전세운-
dc.contributor.author정석종-
dc.contributor.author유한수-
dc.date.accessioned2021-09-29T00:39:14Z-
dc.date.available2021-09-29T00:39:14Z-
dc.date.issued2021-05-
dc.identifier.issn1387-2877-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183972-
dc.description.abstractBackground: The relationship among amyloid-β (Aβ) deposition on amyloid positron emission tomography (PET), cortical metabolism on 18F-fluoro-2-deoxy-D-glucose (FDG)-PET, and clinical diagnosis has not been elucidated for both Alzheimer's disease (AD) and Lewy body disease (LBD). Objective: We investigated the patterns of cerebral metabolism according to the presence of AD and LBD. Methods: A total of 178 subjects were enrolled including 42 pure AD, 32 pure LBD, 34 Lewy body variant AD (LBVAD), 15 LBD with amyloid, 26 AD with dementia with Lewy bodies (DLB), and 29 control subjects. Pure AD, LBVAD, and AD with DLB groups had biomarker-supported diagnoses of typical AD, while pure LBD, LBD with amyloid, and AD with DLB groups had biomarker-supported diagnoses of typical LBD. Typical AD and LBD with amyloid showed amyloid-positivity on 18F-florbetaben (FBB) PET, while typical LBD and LBVAD had abnormalities on dopamine transporter PET. We measured regional patterns of glucose metabolism using FDG-PET and evaluated their relationship with AD and LBD. Results: Compared with control group, typical AD and typical LBD commonly exhibited hypometabolism in the bilateral temporo-parietal junction, precuneus, and posterior cingulate cortex. Typical AD showed an additional hypometabolism in the entorhinal cortex, while patients with dopamine transporter abnormality-supported diagnosis of LBD showed diffuse hypometabolism that spared the sensory-motor cortex. Although the diffuse hypometabolism in LBD also involved the occipital cortex, prominent occipital hypometabolism was only seen in LBD with amyloid group. Conclusion: Combining clinical and metabolic evaluations may enhance the diagnostic accuracy of AD, LBD, and mixed disease cases.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOS Press-
dc.relation.isPartOfJOURNAL OF ALZHEIMERS DISEASE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEffect of Alzheimer's Disease and Lewy Body Disease on Metabolic Changes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorSeun Jeon-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorJin Ho Jung-
dc.contributor.googleauthorKyoungwon Baik-
dc.contributor.googleauthorYoung H Sohn-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorAlan C Evans-
dc.contributor.googleauthorByoung Seok Ye-
dc.identifier.doi10.3233/JAD-201094-
dc.contributor.localIdA05133-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA02550-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA06105-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ01231-
dc.identifier.eissn1875-8908-
dc.identifier.pmid33459638-
dc.identifier.urlhttps://content.iospress.com/articles/journal-of-alzheimers-disease/jad201094-
dc.subject.keywordAlzheimer’s disease-
dc.subject.keywordamyloid-
dc.subject.keywordglucose metabolism-
dc.subject.keywordlewy body disease-
dc.contributor.alternativeNameBaik, Kyoungwon-
dc.contributor.affiliatedAuthor백경원-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor윤미진-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor전세운-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume79-
dc.citation.number4-
dc.citation.startPage1471-
dc.citation.endPage1487-
dc.identifier.bibliographicCitationJOURNAL OF ALZHEIMERS DISEASE, Vol.79(4) : 1471-1487, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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