0 220

Cited 0 times in

Improvement of the mechanical and biological properties of bioactive glasses by the addition of zirconium oxide (ZrO 2 ) as a synthetic bone graft substitute

Authors
 Tae-Yun Kang  ;  Ji-Young Seo  ;  Jeong-Hyun Ryu  ;  Kwang-Mahn Kim  ;  Jae-Sung Kwon 
Citation
 JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Vol.109(7) : 1196-1208, 2021-07 
Journal Title
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN
 1549-3296 
Issue Date
2021-07
Keywords
bioactive glass ; biological properties ; bone graft substitute ; mechanical properties ; zirconium oxide (ZrO2)
Abstract
In this study, mechanical properties of bioactive glass (BAG) synthetic bone graft substitute was improved by containing ZrO2 (ZrO2 -BAG), while maintaining advantageous biological properties of BAG such as osteoinductive and osteoconductive properties. The ZrO2 -BAG was produced by adding ZrO2 in the following proportions to replace Na2 O in 45S5 BAG: 1% (Zr1-BAG), 3% (Zr3-BAG), 6% (Zr6-BAG), and 12% (Zr12-BAG). Properties including XRD, XPS, SEM, DSC, fracture toughness, and Vickers microhardness were evaluated. To assess the biological properties, Ca/P apatite formation, ion release, degradation rate, cell proliferation, ALP activity (ALP), and alizarin red S staining assay (ARS) were evaluated. Also, expression of osteogenic differentiation markers, Osteopontin (OPN), confirmed by immunofluorescence staining. Finally, an in vivo test was carried out to by implanting ZrO2 -BAG into the subcutaneous tissue of rats. The results of each test were statistically analyzed with one-way ANOVA followed by Tukey's post hoc statistical test. Amorphous ZrO2 -BAG was successfully produced with increased mechanical properties as the ZrO2 content was increased. Additionally, ZrO2 -BAG exhibited a slower ion release and degradation rate compare to BAG without ZrO2 . Bioactivity of ZrO2 -BAG was confirmed with apatite layer formed on the surface, significantly higher proliferation rate and significantly enhanced ALP and the degree of ARS of the cells compare to respective controls. The tissue reactions observed in the in vivo study showed neo-formed vessels after implantation of ZrO2 -BAG.
Full Text
https://onlinelibrary.wiley.com/doi/10.1002/jbm.a.37113
DOI
10.1002/jbm.a.37113
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kang, Tae-Yun(강태윤) ORCID logo https://orcid.org/0000-0003-0447-9605
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183964
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links